Jeff Botbyl
Overview
Explore the profile of Jeff Botbyl including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
49
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0
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Recent Articles
1.
Koch K, Smith D, Botbyl J, Arya N, Briley L, Cartee L, et al.
Clin Pharmacol Drug Dev
. 2016 May;
4(6):449-53.
PMID: 27137717
The potential for an interaction between lapatinib and absorption of the P-glycoprotein (ABCB1) substrate digoxin at a therapeutic dose in breast cancer patients was characterized. Seventeen women with HER2-positive metastatic...
2.
Suttle A, Grossmann K, Ouellet D, Richards-Peterson L, Aktan G, Gordon M, et al.
J Clin Pharmacol
. 2014 Dec;
55(4):392-400.
PMID: 25449654
The induction of CYP2C9 by dabrafenib using S-warfarin as a probe and the effects of a CYP3A inhibitor (ketoconazole) and a CYP2C8 inhibitor (gemfibrozil) on dabrafenib pharmacokinetics were evaluated in...
3.
Bennouna J, Deslandres M, Senellart H, de Labareyre C, Ruiz-Soto R, Wixon C, et al.
Invest New Drugs
. 2014 Sep;
33(1):138-47.
PMID: 25248752
Background: Pazopanib is a multi-targeted tyrosine kinase inhibitor shown to be clinically active in the treatment of various cancer types. This study aimed to evaluate the maximum tolerated regimen (MTR),...
4.
Devriese L, Koch K, Mergui-Roelvink M, Matthys G, Ma W, Robidoux A, et al.
Invest New Drugs
. 2013 Dec;
32(3):481-8.
PMID: 24346280
Aim: To quantify the effect of food on the systemic exposure of lapatinib at steady state when administered 1 h before and after meals, and to observe the safety and...