Jean M Prahl
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Explore the profile of Jean M Prahl including associated specialties, affiliations and a list of published articles.
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11
Citations
225
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Recent Articles
1.
Wang Y, Marling S, Martino V, Prahl J, Deluca H
J Steroid Biochem Mol Biol
. 2016 Apr;
163:98-102.
PMID: 27108944
Ultraviolet B (UVB) light suppresses the development of multiple sclerosis (MS) in patients and experimental autoimmune encephalomyelitis (EAE) in mice. Although vitamin D3 is produced by ultraviolet light, the suppression...
2.
Deluca H, Prahl J, Plum L
Arch Biochem Biophys
. 2010 Oct;
505(2):226-30.
PMID: 20965147
Vitamin D intoxication was produced with oral doses of either vitamin D₃ or 25-hydroxyvitamin D₃ in CYP27B1 -/- (1α-hydroxylase knockout) and wild-type mice. These compounds were equally toxic in wild-type...
3.
Vanhooke J, Prahl J, Kimmel-Jehan C, Mendelsohn M, Danielson E, Healy K, et al.
Proc Natl Acad Sci U S A
. 2005 Dec;
103(1):75-80.
PMID: 16371465
The hormonally active form of vitamin D(3),1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is synthesized in the kidney through a tightly regulated reaction catalyzed by 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase), the product of the CYP27B1 gene....
4.
Healy K, Vanhooke J, Prahl J, Deluca H
Proc Natl Acad Sci U S A
. 2005 Mar;
102(13):4724-8.
PMID: 15769857
The vitamin D receptor (VDR) is a nuclear transcription factor responsible for mediating the biological activities of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. Renal and parathyroid gland VDR content is an important factor...
5.
Grzywacz P, Plum L, Sicinska W, Sicinski R, Prahl J, Deluca H
J Steroid Biochem Mol Biol
. 2004 Jul;
89-90(1-5):13-7.
PMID: 15225739
In continuing efforts towards the synthesis of biologically active vitamin D compounds of potential therapeutic value, new 2-methylene-1alpha-hydroxy-19-norvitamin D(3) analogs 3 and 4 with modified alkyl side chains have been...
6.
Plum L, Prahl J, Ma X, Sicinski R, Gowlugari S, Clagett-Dame M, et al.
Proc Natl Acad Sci U S A
. 2004 May;
101(18):6900-4.
PMID: 15118084
Since the discovery of the active metabolite of vitamin D, i.e., 1alpha,25-dihydroxyvitamin D3, there has been a continuous effort to synthesize analogs able to carry out many of the functions...
7.
Healy K, Zella J, Prahl J, Deluca H
Proc Natl Acad Sci U S A
. 2003 Aug;
100(17):9733-7.
PMID: 12900504
Renal vitamin D receptor (VDR) is required for 1,25-dihydroxyvitamin D3-[1,25(OH)2D3]-induced renal reabsorption of calcium and for 1,25(OH)2D3-induced 1,25(OH)2D3 24-hydroxylase. The long-term effect of vitamin D and dietary calcium on the...
8.
Sicinski R, Rotkiewicz P, Kolinski A, Sicinska W, Prahl J, Smith C, et al.
J Med Chem
. 2002 Jul;
45(16):3366-80.
PMID: 12139448
Novel 19-nor analogues of 1alpha,25-dihydroxyvitamin D(3) were prepared and substituted at C-2 with an ethylidene group. The synthetic pathway was via Wittig-Horner coupling of the corresponding A-ring phosphine oxides with...
9.
Zierold C, Mings J, Prahl J, Reinholz G, Deluca H
Arch Biochem Biophys
. 2002 Jul;
404(1):18-24.
PMID: 12127065
The regulation of the 25-hydroxyvitamin D(3)-24-hydroxylase gene by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) has been extensively studied. It is well established that two vitamin D response elements in the promoter are responsible...
10.
Ogunkolade B, Boucher B, Prahl J, Bustin S, Burrin J, Noonan K, et al.
Diabetes
. 2002 Jun;
51(7):2294-300.
PMID: 12086963
Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the insulin resistance syndrome. As VDR polymorphisms have no known functional significance, these...