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Jean Laurent Casanova

Explore the profile of Jean Laurent Casanova including associated specialties, affiliations and a list of published articles. Areas
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Articles 36
Citations 902
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Recent Articles
1.
Guironnet-Paquet A, Hamzeh-Cognasse H, Berard F, Cognasse F, Richard J, Yonis H, et al.
Front Immunol . 2025 Feb; 15:1492672. PMID: 39896810
Background: Immunological disturbances (anti-type I IFN auto-antibody production, cytokine storm, lymphopenia, T-cell hyperactivation and exhaustion) are responsible for disease exacerbation during severe COVID-19 infections. Methods: In this study, we set...
2.
Aissaoui O, Moundir A, Drissi Boughanbour A, El Bakkouri J, Benhsaien I, Ailal F, et al.
Tunis Med . 2025 Jan; 103(1):93-97. PMID: 39812200
Introduction: Pediatric sepsis remains a leading cause of morbidity and mortality in Africa. Nearly half of pediatric sepsis deaths occur in previously healthy children. The role of inborn errors of...
3.
Fadil I, Benhsaien I, El Bakkouri J, Jeddane L, Benaajiba N, Rada N, et al.
Tunis Med . 2024 Oct; 102(10):696-701. PMID: 39441153
Introduction: Hyper-IgE syndrome is a group of inborn errors of immunity, some of which are syndromic, characterized clinically by the classic triad of chronic eczema, cutaneous and/or pulmonary staphylococcal infections...
4.
Fadil I, Ailal F, Beziat V, Casanova J, Boisson B, Bousfiha A
Tunis Med . 2024 Mar; 101(12):862-870. PMID: 38477192
The detection of a high serum immunoglobulin E (IgE) level is first suggestive of allergy, atopy or parasitosis. However, some very high values can be a sign of more severe...
5.
Bonagura V, Casanova J
J Clin Immunol . 2023 Dec; 44(1):31. PMID: 38133721
No abstract available.
6.
Cognasse F, Hamzeh-Cognasse H, Rosa M, Corseaux D, Bonneaudeau B, Pierre C, et al.
EBioMedicine . 2022 Dec; 87:104414. PMID: 36535107
Background: COVID-19 convalescent plasma (CCP) contains neutralising anti-SARS-CoV-2 antibodies that may be useful as COVID-19 passive immunotherapy in patients at risk of developing severe disease. Such plasma from convalescent patients...
7.
Smith N, Posseme C, Bondet V, Sugrue J, Townsend L, Charbit B, et al.
Nat Commun . 2022 Nov; 13(1):7254. PMID: 36434007
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death. We previously reported reduced type I interferon in severe...
8.
Rezaei M, Marjani M, Mirahmadi A, Bineshfar N, Mohammadpour H, Pourabdollah Toutkaboni M, et al.
Int Arch Allergy Immunol . 2022 Oct; 184(1):98-108. PMID: 36244330
Introduction: Cytokine storm and critical COVID-19 pneumonia are caused in at least 10% of patients by inborn errors of or auto-Abs to type I IFNs. The pathogenesis of life-threatening COVID-19...
9.
Belaid B, Lamara Mahammed L, Drali O, Oussaid A, Touri N, Melzi S, et al.
Front Immunol . 2022 May; 13:900091. PMID: 35529857
Background: Inborn errors of immunity (IEI) predispose patients to various infectious and non-infectious complications. Thanks to the development and expanding use of flow cytometry and increased awareness, the diagnostic rate...
10.
Brodin P, Casari G, Townsend L, OFarrelly C, Tancevski I, Loffler-Ragg J, et al.
Nat Med . 2022 Apr; 28(5):879-882. PMID: 35383311
No abstract available.