Jean-Pierre Changeux
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Explore the profile of Jean-Pierre Changeux including associated specialties, affiliations and a list of published articles.
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168
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8883
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Recent Articles
1.
Avstrikova M, Milan Rodriguez P, Burke S, Hibbs R, Changeux J, Cecchini M
Proc Natl Acad Sci U S A
. 2025 Feb;
122(7):e2420993122.
PMID: 39946538
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in neuronal signaling throughout the nervous system. Its implication in neurological disorders and inflammation...
2.
Farisco M, Evers K, Changeux J
Neural Netw
. 2024 Sep;
180:106714.
PMID: 39270349
We here analyse the question of developing artificial consciousness from an evolutionary perspective, taking the evolution of the human brain and its relation with consciousness as a reference model or...
3.
Burke S, Avstrikova M, Noviello C, Mukhtasimova N, Changeux J, Thakur G, et al.
Cell
. 2024 Feb;
187(5):1160-1176.e21.
PMID: 38382524
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays an important role in cholinergic signaling throughout the nervous system. Its unique physiological characteristics and implications in...
4.
Cecchini M, Corringer P, Changeux J
Annu Rev Biochem
. 2024 Feb;
93(1):339-366.
PMID: 38346274
The nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent...
5.
Changeux J
C R Biol
. 2023 Dec;
346(S2):9-13.
PMID: 38131160
Working with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was...
6.
Farisco M, Changeux J
Neurosci Conscious
. 2023 Jun;
2023(1):niad016.
PMID: 37342235
This paper investigates the compatibility between the theoretical framework of the global neuronal workspace theory (GNWT) of conscious processing and the perturbational complexity index (PCI). Even if it has been...
7.
Hilgetag C, Goulas A, Changeux J
Netw Neurosci
. 2023 Mar;
6(4):950-959.
PMID: 36875013
What structural and connectivity features of the human brain help to explain the extraordinary human cognitive abilities? We recently proposed a set of relevant connectomic fundamentals, some of which arise...
8.
Changeux J
C R Biol
. 2023 Feb;
345(3):7-20.
PMID: 36852593
Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally. All his life, his constant preoccupation will be...
9.
Hublin J, Changeux J
C R Biol
. 2023 Feb;
345(2):57-75.
PMID: 36847465
Recent advances in neurobiology, paleontology, and paleogenetics allow us to associate changes in brain size and organization with three main "moments" of increased behavioral complexity and, more speculatively, language development....
10.
Shi S, Lefebvre S, Peverini L, Cerdan A, Milan Rodriguez P, Gielen M, et al.
Nat Commun
. 2023 Feb;
14(1):795.
PMID: 36781912
Pentameric ligand-gated ion channel mediate signal transduction at chemical synapses by transiting between resting and open states upon neurotransmitter binding. Here, we investigate the gating mechanism of the glycine receptor...