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Jean-Michel Fustin

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Articles 35
Citations 1421
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Recent Articles
1.
Chao Y, Lee Y, Tseng C, Wang L, Hsia K, Chen H, et al.
ACS Nano . 2024 Jan; 18(6):4822-4839. PMID: 38285698
Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology. Existing methods have struggled with complex protocols, unreliable reproducibility, high immunogenicity,...
2.
Hitrec T, Petit C, Cryer E, Muir C, Tal N, Fustin J, et al.
iScience . 2023 Mar; 26(2):106002. PMID: 36866044
Timed daily access to a running-wheel (scheduled voluntary exercise; SVE) synchronizes rodent circadian rhythms and promotes stable, 24h rhythms in animals with genetically targeted impairment of neuropeptide signaling ( mice)....
3.
Fukumoto K, Ito K, Saer B, Taylor G, Ye S, Yamano M, et al.
Commun Biol . 2022 Apr; 5(1):313. PMID: 35383287
The global dietary supplement market is valued at over USD 100 billion. One popular dietary supplement, S-adenosylmethionine, is marketed to improve joints, liver health and emotional well-being in the US...
4.
Fustin J
J Biol Rhythms . 2022 Apr; 37(3):235-248. PMID: 35382619
Methylation, that is, the transfer or synthesis of a -CH group onto a target molecule, is a pervasive biochemical modification found in organisms from bacteria to humans. In mammals, a...
5.
Lin H, Huang Y, Fustin J, Doi M, Chen H, Lai H, et al.
Nat Commun . 2021 Jan; 12(1):645. PMID: 33510150
Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region...
6.
Greco C, Cervantes M, Fustin J, Ito K, Ceglia N, Samad M, et al.
Sci Adv . 2020 Dec; 6(51). PMID: 33328229
Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report...
7.
Fustin J, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, et al.
Commun Biol . 2020 Jun; 3(1):295. PMID: 32499511
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Fustin J, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, et al.
Commun Biol . 2020 May; 3(1):211. PMID: 32376902
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that...
9.
Fustin J, Li M, Gao B, Chen Q, Cheng T, Stewart A
Curr Opin Pharmacol . 2019 Oct; 48:127-136. PMID: 31600661
Organoids, bioprinted mini-tissues and body-on-a-chip technologies are poised to transform the practice of preclinical pharmacology, with a view to achieving better predictive value. We review the need for further refinement...
10.
Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, et al.
Nat Commun . 2019 Jun; 10(1):2563. PMID: 31189882
Non-coding cis-regulatory elements are essential determinants of development, but their exact impacts on behavior and physiology in adults remain elusive. Cis-element-based transcriptional regulation is believed to be crucial for generating...