Jean-Benoit Le Luduec
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Explore the profile of Jean-Benoit Le Luduec including associated specialties, affiliations and a list of published articles.
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31
Citations
971
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Recent Articles
1.
Panjwani M, Grassmann S, Sottile R, Le Luduec J, Kontopoulos T, van der Ploeg K, et al.
Front Immunol
. 2025 Jan;
15:1499492.
PMID: 39742279
Development of antigen-specific memory upon pathogen exposure is a hallmark of the adaptive immune system. While natural killer (NK) cells are considered part of the innate immune system, humans exposed...
2.
Le Luduec J, Kontopoulos T, Panjwani M, Sottile R, Liu H, Schafer G, et al.
Blood Adv
. 2024 Aug;
8(20):5382-5399.
PMID: 39158076
CD94/NKG2A is a heterodimeric receptor commonly found on natural killer (NK) and T cells, and its interaction with its ligand HLA-E on adjacent cells leads to inhibitory signaling and cell...
3.
Mehanna N, Pradhan A, Kaur R, Kontopoulos T, Rosati B, Carlson D, et al.
bioRxiv
. 2024 Apr;
PMID: 38659858
Natural Killer (NK) cells can recognize and kill -infected cells in vitro, however their role after natural human exposure has not been well-studied. To identify -responsive NK cell populations, we...
4.
Panjwani M, Grassmann S, Sottile R, Le Luduec J, Kontopoulos T, van der Ploeg K, et al.
bioRxiv
. 2023 Oct;
PMID: 37790504
Development of antigen-specific memory upon pathogen exposure is a hallmark of the adaptive immune system. While natural killer (NK) cells are considered part of the innate immune system, humans exposed...
5.
Santosa E, Kim H, Ruckert T, Le Luduec J, Abbasi A, Wingert C, et al.
Nat Immunol
. 2023 Sep;
24(10):1685-1697.
PMID: 37697097
Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features, including antigen specificity, clonal expansion and memory. As such, NK cells share many transcriptional and epigenetic programs with...
6.
Shahid S, Ceglia N, Le Luduec J, McPherson A, Spitzer B, Kontopoulos T, et al.
Blood Adv
. 2023 Jun;
7(17):5069-5081.
PMID: 37327118
Although allogeneic hematopoietic cell transplant (allo-HCT) is curative for high-risk pediatric acute myeloid leukemia (AML), disease relapse remains the primary cause of posttransplant mortality. To identify pressures imposed by allo-HCT...
7.
van der Ploeg K, Sottile R, Kontopoulos T, Shaffer B, Papanicolaou G, Maloy M, et al.
Blood Adv
. 2023 May;
7(19):5784-5798.
PMID: 37196646
Cytomegalovirus (CMV) infection is associated with the expansion of a mature NKG2C+FcεR1γ- natural killer (NK) cell population. The exact mechanism underlying the emergence of NKG2C+ NK cells, however, remains unknown....
8.
Wu Z, Lau C, Sottile R, Le Luduec J, Panjwani M, Conaty P, et al.
J Immunol
. 2021 Oct;
207(10):2534-2544.
PMID: 34625521
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers,...
9.
Sottile R, Panjwani M, Lau C, Daniyan A, Tanaka K, Barker J, et al.
Sci Immunol
. 2021 Sep;
6(63):eabe6968.
PMID: 34559552
CD8 T cells not only are critical mediators of adaptive immunity but also may exhibit innate-like properties such as surface expression of NKG2C, an activating receptor typically associated with natural...
10.
Wiedemann G, Santosa E, Grassmann S, Sheppard S, Le Luduec J, Adams N, et al.
Nat Immunol
. 2021 Apr;
22(5):627-638.
PMID: 33859404
Cytokine signaling via signal transducer and activator of transcription (STAT) proteins is crucial for optimal antiviral responses of natural killer (NK) cells. However, the pleiotropic effects of both cytokine and...