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Jayashri Ghosh

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Articles 20
Citations 274
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Recent Articles
1.
Le B, Vekariya U, Toma M, Nieborowska-Skorska M, Caron M, Gozdecka M, et al.
bioRxiv . 2024 Oct; PMID: 39411165
Myeloid malignancies carrying somatic DNMT3A mutations (DNMT3Amut) are usually resistant to standard therapy. DNMT3Amut leukemia cells accumulate toxic DNA double strand breaks (DSBs) and collapsed replication forks, rendering them dependent...
2.
Park P, Keith K, Calendo G, Jelinek J, Madzo J, Gharaibeh R, et al.
Gut Microbes . 2024 Jun; 16(1):2363012. PMID: 38860458
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between...
3.
Thej C, Roy R, Cheng Z, Garikipati V, Truongcao M, Joladarashi D, et al.
NPJ Regen Med . 2024 Apr; 9(1):17. PMID: 38684697
Historically, a lower incidence of cardiovascular diseases (CVD) and related deaths in women as compared with men of the same age has been attributed to female sex hormones, particularly estrogen...
4.
Chang W, Ghosh J, Cooper H, Vanderveer L, Schultz B, Zhou Y, et al.
Cancers (Basel) . 2023 Jun; 15(11). PMID: 37296911
Purpose: The purpose of this study was to assess the effect of folic acid (FA) supplementation on colitis-associated colorectal cancer (CRC) using the azoxymethane/dextran sulfate sodium (AOM/DSS) model. Methods: Mice...
5.
Vekariya U, Toma M, Nieborowska-Skorska M, Le B, Caron M, Kukuyan A, et al.
Blood . 2022 Dec; 141(19):2372-2389. PMID: 36580665
Leukemia cells accumulate DNA damage, but altered DNA repair mechanisms protect them from apoptosis. We showed here that formaldehyde generated by serine/1-carbon cycle metabolism contributed to the accumulation of toxic...
6.
Dolinko A, Schultz B, Ghosh J, Kalliora C, Mainigi M, Coutifaris C, et al.
Clin Epigenetics . 2022 Oct; 14(1):129. PMID: 36243864
Background: Alterations in the epigenome are a risk factor in multiple disease states. We have demonstrated in the past that disruption of the epigenome during early pregnancy or periconception, as...
7.
Ghosh J, Schultz B, Chan J, Wultsch C, Singh R, Shureiqi I, et al.
Cancer Prev Res (Phila) . 2022 Oct; 15(11):755-766. PMID: 36219239
Prevention Relevance: Our study identifies an epigenetically distinct OMP group in the normal mucosa of patients with colorectal cancer that is characterized by a disrupted methylome, altered gene expression, and...
8.
Mani S, Ghosh J, Rhon-Calderon E, Lan Y, Ord T, Kalliora C, et al.
Hum Mol Genet . 2022 Jun; 31(22):3855-3872. PMID: 35717573
In vitro fertilization (IVF) is associated with DNA methylation abnormalities and a higher incidence of adverse pregnancy outcomes. However, which exposure(s), among the many IVF interventions, contributes to these outcomes...
9.
Pradhan S, Das A, Ghosh J
J Neurosci Rural Pract . 2020 Mar; 11(1):89-94. PMID: 32140009
 The diagnosis of migraine depends on various characteristics of headache with their associated constitutional symptoms such as nausea, vomiting, photophobia, and phonophobia. Relatively severe intensity, throbbing character, unilaterality, and aggravation...
10.
Mani S, Ghosh J, Coutifaris C, Sapienza C, Mainigi M
Epigenetics . 2019 Jul; 15(1-2):12-25. PMID: 31328632
Children conceived by Assisted Reproductive Technologies (ART) are at moderately increased risk for a number of undesirable outcomes, including low birth weight. Whether the additional risk is associated with specific...