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» Authors » Jayagopala Reddy

Jayagopala Reddy

Explore the profile of Jayagopala Reddy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 862
Followers 0
Related Specialties
Allergy & Immunology
Science
General Medicine
Top 10 Co-Authors
Vijay K Kuchroo
Raymond A Sobel
Zsolt Illes
Hanspeter Waldner
Jack L Strominger
Joel N H Stern
Laura Santambrogio
Celia F Brosnan
Estelle Bettelli
Kai W Wucherpfennig
Published In
J Immunol
Proc Natl Acad Sci U S A
Int Immunol
Eur J Immunol
J Autoimmun
Affiliations
Soon will be listed here.
Recent Articles
1.
Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
Lin Y, Sakuraba S, Massilamany C, Reddy J, Tanaka Y, Miyake S, et al.
J Autoimmun . 2023 Sep; 140:103094. PMID: 37716077
Sensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity...
2.
Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background
Illes Z, Waldner H, Reddy J, Anderson A, Sobel R, Kuchroo V
Int Immunol . 2007 Sep; 19(10):1235-48. PMID: 17804690
Myelin proteolipid protein (PLP) 139-151 is an immunodominant peptide that induces experimental autoimmune encephalomyelitis (EAE) in H-2(s) SJL/J mice. While PLP 139-151-specific TCR transgenic (tg) 4E3 mice develop fulminant spontaneous...
3.
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen T, et al.
Nat Med . 2007 Mar; 13(4):423-31. PMID: 17384649
Treatment with ex vivo-generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases. However, the dynamics and function of T-reg in autoimmunity are...
4.
Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells
Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo V, Weiner H
Int Immunol . 2006 Mar; 18(4):495-503. PMID: 16540527
SJL mice are highly susceptible to proteolipid protein (PLP) 139-151-induced experimental allergic encephalomyelitis (EAE). The disease is characterized by a relapsing-remitting type of paralysis. However, the mechanism by which animals...
5.
Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species
Greenfield E, Reddy J, Lees A, Dyer C, Koul O, Nguyen K, et al.
J Neurosci Res . 2006 Jan; 83(3):415-31. PMID: 16416423
Myelin proteolipid protein (PLP), the major protein of mammalian CNS myelin, is a member of the proteolipid gene family (pgf). It is an evolutionarily conserved polytopic integral membrane protein and...
6.
Copolymer effects on microglia and T cells in the central nervous system of humanized mice
Illes Z, Stern J, Keskin D, Reddy J, Brosnan C, Waldner H, et al.
Eur J Immunol . 2005 Nov; 35(12):3683-93. PMID: 16259003
The random amino acid copolymers FYAK and VWAK ameliorate EAE in a humanized mouse model expressing both a human transgenic myelin basic protein (MBP)85-99-specific T cell receptor and HLA-DR2. Here...
7.
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions
Dardalhon V, Schubart A, Reddy J, Meyers J, Monney L, Sabatos C, et al.
J Immunol . 2005 Jul; 175(3):1558-65. PMID: 16034094
Surface molecules that are differentially expressed on Th1 and Th2 cells may be useful in regulating specific immune responses in vivo. Using a panel of mAbs, we have identified murine...
8.
T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production
Illes Z, Waldner H, Reddy J, Bettelli E, Nicholson L, Kuchroo V
J Immunol . 2005 Jul; 175(3):1491-7. PMID: 16034086
Cross-reactive activation of potentially autoreactive T cells by high-affinity nonself ligands may be important in breaking self-tolerance in autoimmunity. In a mouse transgenic for a cross-reactive TCR, we have previously...
9.
Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis
Stern J, Illes Z, Reddy J, Keskin D, Fridkis-Hareli M, Kuchroo V, et al.
Proc Natl Acad Sci U S A . 2005 Jan; 102(5):1620-5. PMID: 15665083
Myelin basic protein (MBP) is a major candidate autoantigen in multiple sclerosis (MS). Its immunodominant epitope, MBP 85-99, forms a complex with human leukocyte antigen (HLA)-DR2 with which multiple sclerosis...
10.
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis
Reddy J, Illes Z, Zhang X, Encinas J, Pyrdol J, Nicholson L, et al.
Proc Natl Acad Sci U S A . 2004 Oct; 101(43):15434-9. PMID: 15492218
SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE...