Jay Kumar
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Citations
320
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Recent Articles
1.
Kowluru R, Kumar J, Malaviya P
Noncoding RNA Res
. 2025 Jan;
11():141-149.
PMID: 39811245
Diabetic retinopathy, a microvascular complication of diabetes, is the leading cause of blindness in adults, but the molecular mechanism of its development remains unclear. Retinal mitochondrial DNA is damaged and...
2.
Kumar J, Malaviya P, Kowluru R
J Diabetes
. 2024 Nov;
16(11):e70009.
PMID: 39558680
Progression of diabetic retinopathy resists arrest even after institution of intensive glycemic control, suggesting a "metabolic memory" phenomenon, but the mechanism responsible for this phenomenon is still elusive. Gene expression...
3.
Malaviya P, Kumar J, Kowluru R
Free Radic Biol Med
. 2024 Oct;
225:821-832.
PMID: 39433112
Diabetic retinopathy is driven by oxidative stress-mitochondrial damage. Activation of ROS producing cytosolic NADPH oxidase 2 (Nox2) in diabetes precedes retinal mitochondrial damage, initiating a vicious cycle of free radicals....
4.
Kumar J, Malaviya P, Kowluru R
Biomedicines
. 2024 Aug;
12(8).
PMID: 39200102
Aim: Hyperglycemia damages mitochondria and downregulates transcription of mtDNA-encoded genes and the long noncoding RNA Lnc, causing mitochondrial genomic instability. The genes encoded by mtDNA are transcribed as large polycistronic...
5.
Kumar J, Kowluru R
Mitochondrion
. 2024 Jun;
78:101925.
PMID: 38944370
In diabetic retinopathy, mitochondrial DNA (mtDNA) is damaged and mtDNA-encoded genes and long noncoding RNA cytochrome B (LncCytB) are downregulated. LncRNAs lack an open reading frame, but they can regulate...
6.
Kumar R, Bernard C, Ullah A, Khan R, Kumar J, Kulevome D, et al.
Comput Biol Med
. 2024 Jun;
177:108646.
PMID: 38824788
Improved data sharing between healthcare providers can lead to a higher probability of accurate diagnosis, more effective treatments, and enhanced capabilities of healthcare organizations. One critical area of focus is...
7.
Kowluru R, Mohammad G, Kumar J
Mol Neurobiol
. 2023 Aug;
61(1):188-199.
PMID: 37596436
Retinopathy fails to halt even after diabetic patients in poor glycemic control try to institute tight glycemic control, suggesting a "metabolic memory" phenomenon, and the experimental models have demonstrated that...
8.
Mohammad G, Kumar J, Kowluru R
Antioxid Redox Signal
. 2023 Jul;
39(13-15):817-828.
PMID: 37464864
Mitochondrial dysfunction is closely associated with the development of diabetic complications. In diabetic retinopathy, electron transport chain is compromised and mitochondrial DNA (mtDNA) is damaged, downregulating transcription of mtDNA-encoded cytochrome...
9.
Alka K, Kumar J, Kowluru R
Front Endocrinol (Lausanne)
. 2023 Jul;
14:1160155.
PMID: 37415667
Introduction: Mitochondrial dynamic plays a major role in their quality control, and the damaged mitochondrial components are removed by autophagy. In diabetic retinopathy, mitochondrial fusion enzyme, mitofusin 2 (Mfn2), is...
10.
Kumar J, Mohammad G, Alka K, Kowluru R
Diabetes
. 2022 Dec;
72(4):520-531.
PMID: 36563021
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