Javier Lopez-Andarias
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Explore the profile of Javier Lopez-Andarias including associated specialties, affiliations and a list of published articles.
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31
Citations
349
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Recent Articles
1.
Roffay C, Garcia-Arcos J, Chapuis P, Lopez-Andarias J, Schneider F, Colom A, et al.
Nat Protoc
. 2024 Aug;
19(12):3457-3469.
PMID: 39210094
Measuring forces within living cells remains a technical challenge. In this Tutorial, we cover the development of hydrophobic mechanosensing fluorescent probes called Flippers, whose fluorescence lifetime depends on lipid packing....
2.
Gutierrez Lopez M, Tan M, Renno G, Jozeliunaite A, Nue-Martinez J, Lopez-Andarias J, et al.
Beilstein J Org Chem
. 2023 Dec;
19:1881-1894.
PMID: 38116243
Anion-π catalysis, introduced in 2013, stands for the stabilization of anionic transition states on π-acidic aromatic surfaces. Anion-π catalysis on carbon allotropes is particularly attractive because high polarizability promises access...
3.
Assies L, Mercier V, Lopez-Andarias J, Roux A, Sakai N, Matile S
Chembiochem
. 2022 May;
23(15):e202200192.
PMID: 35535626
Labeled ammonium cations with pK ∼7.4 accumulate in acidic organelles because they can be neutralized transiently to cross the membrane at cytosolic pH 7.2 but not at their internal pH<5.5....
4.
Garcia-Calvo J, Lopez-Andarias J, Maillard J, Mercier V, Roffay C, Roux A, et al.
Chem Sci
. 2022 Mar;
13(7):2086-2093.
PMID: 35308858
HydroFlippers are introduced as the first fluorescent membrane tension probes that report simultaneously on membrane compression and hydration. The probe design is centered around a sensing cycle that couples the...
5.
Assies L, Garcia-Calvo J, Piazzolla F, Sanchez S, Kato T, Reymond L, et al.
Chimia (Aarau)
. 2021 Dec;
75(12):1004-1011.
PMID: 34920768
This article describes four fluorescent membrane tension probes that have been designed, synthesized, evaluated, commercialized and applied to current biology challenges in the context of the NCCR Chemical Biology. Their...
6.
Martinent R, Tawffik S, Lopez-Andarias J, Moreau D, Laurent Q, Matile S
Chem Sci
. 2021 Nov;
12(41):13922-13929.
PMID: 34760179
The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated uptake is reported. This is important because most orthodox systems, including polycationic cell-penetrating peptides, fail to deliver efficiently...
7.
Lopez-Andarias J, Eblighatian K, Pasquer Q, Assies L, Sakai N, Hoogendoorn S, et al.
Angew Chem Int Ed Engl
. 2021 Nov;
61(1):e202113163.
PMID: 34734671
Mechanosensitive flipper probes are attracting interest as fluorescent reporters of membrane order and tension in biological systems. We introduce PhotoFlippers, which contain a photocleavable linker and an ultralong tether between...
8.
Laurent Q, Martinent R, Lim B, Pham A, Kato T, Lopez-Andarias J, et al.
JACS Au
. 2021 Sep;
1(6):710-728.
PMID: 34467328
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive agents. A short chronology from...
9.
Lopez-Andarias J, Strakova K, Martinent R, Jimenez-Rojo N, Riezman H, Sakai N, et al.
JACS Au
. 2021 Sep;
1(2):221-232.
PMID: 34467286
To image membrane tension in selected membranes of interest (MOI) inside living systems, the field of mechanobiology requires increasingly elaborated small-molecule chemical tools. We have recently introduced HaloFlipper, i.e., a...
10.
Cheng Y, Pham A, Kato T, Lim B, Moreau D, Lopez-Andarias J, et al.
Chem Sci
. 2021 Jun;
12(2):626-631.
PMID: 34163793
Ellman's reagent has caused substantial confusion and concern as a probe for thiol-mediated uptake because it is the only established inhibitor available but works neither efficiently nor reliably. Here we...