Jason R Gotlib
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Explore the profile of Jason R Gotlib including associated specialties, affiliations and a list of published articles.
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24
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966
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Recent Articles
11.
Sasaki K, Gotlib J, Mesa R, Newberry K, Ravandi F, Cortes J, et al.
Leuk Lymphoma
. 2015 Feb;
56(7):2092-7.
PMID: 25641433
The clinical safety and efficacy of IPI-926 was evaluated in 14 patients with myelofibrosis in a phase II study. Patients received 160 mg IPI-926 orally in continuous 28-day cycles. The...
12.
Ohgami R, Ma L, Merker J, Gotlib J, Schrijver I, Zehnder J, et al.
Mod Pathol
. 2014 Nov;
28(5):706-14.
PMID: 25412851
We assessed the frequency and clinicopathologic significance of 19 genes currently identified as significantly mutated in myeloid neoplasms, RUNX1, ASXL1, TET2, CEBPA, IDH1, IDH2, DNMT3A, FLT3, NPM1, TP53, NRAS, EZH2,...
13.
Weinberg O, Ohgami R, Ma L, Seo K, Ren L, Gotlib J, et al.
Am J Clin Pathol
. 2014 Jul;
142(2):190-5.
PMID: 25015859
Objectives: Acute myeloid leukemia (AML) with monosomal karyotype (MK) recently has been reported to be associated with worse outcome than the traditional complex karyotype. Methods: In this retrospective study of...
14.
Ludwig L, Gazda H, Eng J, Eichhorn S, Thiru P, Ghazvinian R, et al.
Nat Med
. 2014 Jun;
20(7):748-53.
PMID: 24952648
Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA), congenital asplenia and T cell leukemia. Yet, how mutations in genes encoding ubiquitously expressed proteins such as these...
15.
Johnson R, Savage N, Chiang T, Gotlib J, Cherry A, Arber D, et al.
Am J Clin Pathol
. 2013 Sep;
140(4):525-35.
PMID: 24045550
Objectives: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). Methods: We retrospectively characterized 40 bone marrow aspirate smears and...
16.
Pollyea D, Zehnder J, Coutre S, Gotlib J, Gallegos L, Abdel-Wahab O, et al.
Haematologica
. 2012 Dec;
98(4):591-6.
PMID: 23242596
There are limited treatment options for older patients with acute myeloid leukemia and prognosis of these patients remains poor, thereby warranting development of novel therapies. We evaluated the efficacy and...
17.
Tyner J, Yang W, Bankhead 3rd A, Fan G, Fletcher L, Bryant J, et al.
Cancer Res
. 2012 Oct;
73(1):285-96.
PMID: 23087056
Kinases are dysregulated in most cancers, but the frequency of specific kinase mutations is low, indicating a complex etiology in kinase dysregulation. Here, we report a strategy to rapidly identify...
18.
Ohgami R, Ma L, Ren L, Weinberg O, Seetharam M, Gotlib J, et al.
Br J Haematol
. 2012 Aug;
159(2):182-90.
PMID: 22924777
To determine the role of DNA methylation in the progression of acute myeloid leukaemia (AML), we analysed the methylation status of ALOX12, GSTM1, HS3ST2 and FZD9 in 127 AML patients....
19.
Liedtke M, Twist C, Medeiros B, Gotlib J, Berube C, Bieber M, et al.
Haematologica
. 2011 Oct;
97(1):30-7.
PMID: 21993685
Background: This phase I trial was conducted to determine the safety and pharmacokinetics of monoclonal antibody 216, a human monoclonal Immunoglobulin M antibody targeting a linear B-cell lactosamine antigen, administered...
20.
McClellan J, Kohrt H, Coutre S, Gotlib J, Majeti R, Alizadeh A, et al.
Haematologica
. 2011 Oct;
97(1):133-6.
PMID: 21993679
Early mortality in acute promyelocytic leukemia has been reported to occur in less than 10% of patients treated in clinical trials. This study reports the incidence and clinical features of...