Jason P Appleton
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Explore the profile of Jason P Appleton including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Woodhouse L, Appleton J, Scutt P, Everton L, Wilkinson G, Caso V, et al.
EClinicalMedicine
. 2022 Feb;
44:101274.
PMID: 35112073
Background: It is not known whether to continue or temporarily stop existing antihypertensive drugs in patients with acute stroke. Methods: We performed a prospective subgroup analysis of patients enrolled into...
12.
Law Z, Appleton J, Scutt P, Roberts I, Salman R, England T, et al.
Stroke
. 2021 Dec;
53(4):1141-1148.
PMID: 34847710
Background: Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic...
13.
Blair G, Janssen E, Stringer M, Thrippleton M, Chappell F, Shi Y, et al.
Stroke
. 2021 Dec;
53(1):29-33.
PMID: 34847709
Background And Purpose: Cerebral small vessel disease-a major cause of stroke and dementia-is associated with cerebrovascular dysfunction. We investigated whether short-term isosorbide mononitrate (ISMN) and cilostazol, alone or in combination,...
14.
Gomindes A, Appleton J, Chugh R, Welch C
Cureus
. 2021 Aug;
13(6):e15912.
PMID: 34336420
Background Sarcopenia (low muscle mass and function) is increasingly recognised to impact the quality of life and patient outcomes. The relationship with brain frailty is unknown. Objectives Assess if muscle...
15.
Appleton J, Mullhi R, Singh N
Br J Hosp Med (Lond)
. 2021 Jan;
82(1):1-9.
PMID: 33512281
The management of acute ischaemic stroke has been revolutionised by effective reperfusion therapies including thrombolysis and mechanical thrombectomy. In particular, mechanical thrombectomy has heralded a new era in stroke medicine....
16.
Appleton J, Woodhouse L, Sprigg N, Wardlaw J, Bath P
Front Neurol
. 2020 Dec;
11:625572.
PMID: 33324341
[This corrects the article DOI: 10.3389/fneur.2020.584038.].
17.
Appleton J, OSullivan S, Hedstrom A, May J, Donnelly R, Sprigg N, et al.
Eur J Neurol
. 2020 Nov;
28(4):1225-1233.
PMID: 33217147
Background And Purpose: Remote ischaemic per-conditioning (RIC) is neuroprotective in experimental ischaemic stroke. Several neurohumoral, vascular and inflammatory mediators are implicated. The effect of RIC on plasma biomarkers was assessed...
18.
Appleton J, Woodhouse L, Sprigg N, Wardlaw J, Bath P
Front Neurol
. 2020 Nov;
11:584038.
PMID: 33193044
Thrombolysis, with or without thrombectomy, for acute ischaemic stroke is associated with an increased risk of intracranial bleeding. We assessed whether treatment with glyceryl trinitrate (GTN), a nitric oxide donor,...
19.
Clancy U, Appleton J, Arteaga C, Doubal F, Bath P, Wardlaw J
Chin Med J (Engl)
. 2020 Oct;
134(2):127-142.
PMID: 33118960
Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive impairment, ischemic or hemorrhagic stroke, problems with mobility, and neuropsychiatric symptoms. The brain damage, seen as...
20.
Law Z, Dineen R, England T, Cala L, Mistri A, Appleton J, et al.
Transl Stroke Res
. 2020 Sep;
12(2):275-283.
PMID: 32902808
Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data...