Jason M Wilham
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Explore the profile of Jason M Wilham including associated specialties, affiliations and a list of published articles.
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12
Citations
1059
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Recent Articles
1.
Elder A, Henderson D, Nalls A, Wilham J, Caughey B, Hoover E, et al.
PLoS One
. 2013 Nov;
8(11):e80203.
PMID: 24224043
Blood-borne transmission of infectious prions during the symptomatic and asymptomatic stages of disease occurs for both human and animal transmissible spongiform encephalopathies (TSEs). The geographical distribution of the cervid TSE,...
2.
Vascellari S, Orru C, Hughson A, King D, Barron R, Wilham J, et al.
PLoS One
. 2012 Nov;
7(11):e48969.
PMID: 23139828
Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion...
3.
McGuire L, Peden A, Orru C, Wilham J, Appleford N, Mallinson G, et al.
Ann Neurol
. 2012 Aug;
72(2):278-85.
PMID: 22926858
Objective: Current cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF 14-3-3, which are not specific...
4.
Orru C, Wilham J, Vascellari S, Hughson A, Caughey B
Prion
. 2012 Mar;
6(2):147-52.
PMID: 22421206
The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils from recombinant PrP(Sen) has served as the basis for several relatively rapid and highly sensitive...
5.
Bessen R, Wilham J, Lowe D, Watschke C, Shearin H, Martinka S, et al.
J Virol
. 2011 Dec;
86(3):1777-88.
PMID: 22130543
In this study, we investigated the role of damage to the nasal mucosa in the shedding of prions into nasal samples as a pathway for prion transmission. Here, we demonstrate...
6.
Peden A, McGuire L, Appleford N, Mallinson G, Wilham J, Orru C, et al.
J Gen Virol
. 2011 Oct;
93(Pt 2):438-449.
PMID: 22031526
Real-time quaking-induced conversion (RT-QuIC) is an assay in which disease-associated prion protein (PrP) initiates a rapid conformational transition in recombinant PrP (recPrP), resulting in the formation of amyloid that can...
7.
Orru C, Wilham J, Raymond L, Kuhn F, Schroeder B, Raeber A, et al.
mBio
. 2011 May;
2(3):e00078-11.
PMID: 21558432
Unlabelled: A key challenge in managing transmissible spongiform encephalopathies (TSEs) or prion diseases in medicine, agriculture, and wildlife biology is the development of practical tests for prions that are at...
8.
Wilham J, Orru C, Bessen R, Atarashi R, Sano K, Race B, et al.
PLoS Pathog
. 2010 Dec;
6(12):e1001217.
PMID: 21152012
A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such measurements have typically required...
9.
Bessen R, Shearin H, Martinka S, Boharski R, Lowe D, Wilham J, et al.
PLoS Pathog
. 2010 Apr;
6(4):e1000837.
PMID: 20419120
This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible...
10.
Orru C, Wilham J, Hughson A, Raymond L, McNally K, Bossers A, et al.
Protein Eng Des Sel
. 2009 Jul;
22(8):515-21.
PMID: 19570812
The pathological isoform of the prion protein (PrP(res)) can serve as a marker for prion diseases, but more practical tests are needed for preclinical diagnosis and sensitive detection of many...