Jason M Hinzman
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Explore the profile of Jason M Hinzman including associated specialties, affiliations and a list of published articles.
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18
Citations
1069
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Recent Articles
1.
Hartings J, Andaluz N, Ross Bullock M, Hinzman J, Mathern B, Pahl C, et al.
JAMA Neurol
. 2019 Dec;
77(4):489-499.
PMID: 31886870
Importance: Advances in treatment of traumatic brain injury are hindered by the inability to monitor pathological mechanisms in individual patients for targeted neuroprotective treatment. Spreading depolarizations, a mechanism of lesion...
2.
Foreman B, Ngwenya L, Stoddard E, Hinzman J, Andaluz N, Hartings J
Neurocrit Care
. 2018 Jun;
29(3):469-480.
PMID: 29949001
Background: We aimed to provide a systematic description of our 2-year experience using a standardized bedside, single burr hole approach to intracranial multimodality monitoring (MMM) in patients with severe traumatic...
3.
Dreier J, Major S, Foreman B, Winkler M, Kang E, Milakara D, et al.
Ann Neurol
. 2018 Jan;
83(2):295-310.
PMID: 29331091
Objective: Restoring the circulation is the primary goal in emergency treatment of cerebral ischemia. However, better understanding of how the brain responds to energy depletion could help predict the time...
4.
Hartings J, York J, Carroll C, Hinzman J, Mahoney E, Krueger B, et al.
Brain
. 2017 Oct;
140(10):2673-2690.
PMID: 28969382
See Ghoshal and Claassen (doi:10.1093/brain/awx226) for a scientific commentary on this article.
Early cortical infarcts are common in poor-grade patients after aneurysmal subarachnoid haemorrhage. There are no animal models of...
5.
Hartings J, Shuttleworth C, Kirov S, Ayata C, Hinzman J, Foreman B, et al.
J Cereb Blood Flow Metab
. 2016 Jun;
37(5):1571-1594.
PMID: 27328690
A modern understanding of how cerebral cortical lesions develop after acute brain injury is based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic depolarization. Treated as separate entities...
6.
Dreier J, Fabricius M, Ayata C, Sakowitz O, Shuttleworth C, Dohmen C, et al.
J Cereb Blood Flow Metab
. 2016 Jun;
37(5):1595-1625.
PMID: 27317657
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism...
7.
Hartings J, Li C, Hinzman J, Shuttleworth C, Ernst G, Dreier J, et al.
J Cereb Blood Flow Metab
. 2016 Jun;
37(5):1857-1870.
PMID: 27286981
Spreading depolarizations cause cortical electrical potential changes over a wide spectral range that includes slow potentials approaching the direct current (or 0 Hz) level. The negative direct current shift (<0.05 ...
8.
Hinzman J, Wilson J, Mazzeo A, Ross Bullock M, Hartings J
J Neurotrauma
. 2015 Nov;
33(19):1775-1783.
PMID: 26586606
Cerebral microdialysis has enabled the clinical characterization of excitotoxicity (glutamate >10 μM) and non-ischemic metabolic crisis (lactate/pyruvate ratio [LPR] >40) as important components of secondary damage in severe traumatic brain...
9.
Hinzman J, Gibson J, Tackla R, Costello M, Burmeister J, Quintero J, et al.
Biosens Bioelectron
. 2015 Jul;
74:512-7.
PMID: 26183072
Throughout the central nervous system extracellular adenosine serves important neuroprotective and neuromodulatory functions. However, current understanding of the in vivo regulation and effects of adenosine is limited by the spatial...
10.
Tackla R, Hinzman J, Foreman B, Magner M, Andaluz N, Hartings J
Neurocrit Care
. 2015 May;
23(3):339-46.
PMID: 25948537
Background: Impairment of cerebrovascular autoregulation is a risk factor for ischemic damage following severe brain injury. Autoregulation can be assessed indirectly using intracranial pressure monitoring as a surrogate of cerebral...