Jason Koval
Overview
Explore the profile of Jason Koval including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
198
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Recent Articles
1.
Zhao Y, Zhou R, Xie B, Liu C, Kalski M, Cham C, et al.
Nat Commun
. 2025 Jan;
16(1):904.
PMID: 39837850
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using...
2.
Zhao Y, Zhou R, Mu Z, Carbonetto P, Zhong X, Xie B, et al.
medRxiv
. 2024 Dec;
PMID: 39711713
Crohn's disease (CD) is a complex inflammatory bowel disease resulting from an interplay of genetic, microbial, and environmental factors. Cell-type-specific contributions to CD etiology and genetic risk are incompletely understood....
3.
Vineis J, Reznikoff W, Antonopoulos D, Koval J, Chang E, Fallon B, et al.
mBio
. 2024 Jan;
15(2):e0278723.
PMID: 38259081
Tetracyclines serve as broad-spectrum antibiotics to treat bacterial infections. The discovery of new tetracycline resistance genes has led to new questions about the underlying mechanisms of resistance, gene transfer, and...
4.
Mullowney M, Fiebig A, Schnizlein M, McMillin M, Rose A, Koval J, et al.
J Bacteriol
. 2024 Jan;
206(1):e0042623.
PMID: 38174933
Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient absorption, regulate host metabolic processes, and influence physiology of the gut microbiota. Both the host and its microbiome...
5.
Zhao Y, Zhou R, Xie B, Liu C, Kalski M, Cham C, et al.
medRxiv
. 2023 Nov;
PMID: 38014192
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using...
6.
Mullowney M, Fiebig A, Schnizlein M, McMillin M, Rose A, Koval J, et al.
bioRxiv
. 2023 Oct;
PMID: 37808758
Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient absorption, regulate host metabolic processes, and influence physiology of the gut microbiota. Both the host and its microbiome...
7.
Mu A, Klare W, Baines S, Ignatius Pang C, Guerillot R, Harbison-Price N, et al.
Nat Commun
. 2023 Mar;
14(1):1530.
PMID: 36934086
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop...
8.
Schnegg-Kaufmann A, Thoms J, Sarower Bhuyan G, Hampton H, Vaughan L, Rutherford K, et al.
Blood
. 2022 Dec;
141(11):1316-1321.
PMID: 36493342
Myelodysplastic neoplasms (MDSs) and chronic myelomonocytic leukemia (CMML) are clonal disorders driven by progressively acquired somatic mutations in hematopoietic stem cells (HSCs). Hypomethylating agents (HMAs) can modify the clinical course...
9.
Dodiya H, Frith M, Sidebottom A, Cao Y, Koval J, Chang E, et al.
Sci Rep
. 2020 May;
10(1):8183.
PMID: 32424118
In preceding efforts, we demonstrated that antibiotic (ABX) cocktail-mediated perturbations of the gut microbiome in two independent transgenic lines, termed APP/PS1 and APPPS1-21, leads to a reduction in Aβ deposition...
10.
Bissett A, Fitzgerald A, Court L, Meintjes T, Mele P, Reith F, et al.
Gigascience
. 2018 Aug;
6(5).
PMID: 30137319
No abstract available.