Jasmeen K Saini

Aim: The central CO chemoreflex is a vital component of respiratory control networks, providing excitatory drive during resting conditions and challenges to blood gas homeostasis. The retrotrapezoid nucleus is a...

Background: The attenuated, genetically engineered vaccinia virus has been shown to be a promising oncolytic virus for the treatment of patients with solid tumors, through both direct cytotoxic and immune-activating...

Introduction: In solid tumor immunotherapy, less than 20% of patients respond to anti-programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) agents. The role of transforming growth factor...

Heterozygous mutations of the transcription factor are responsible for Congenital Central Hypoventilation Syndrome, a neurological disorder characterized by inadequate respiratory response to hypercapnia and life-threatening hypoventilation during sleep. Although no...

Sleep irregularities and respiratory events (apnea, O desaturation or a combination thereof) are often present in the infant population. While inspiration is the main active process in the act of...

Success in solid tumor chimeric antigen receptor (CAR) T-cell therapy requires overcoming several barriers, including lung sequestration, inefficient accumulation within the tumor, and target-antigen heterogeneity. Understanding CAR T-cell kinetics can...

Breathing is most vulnerable to apneas and other disturbances during sleep in both humans and rodents, especially in the newborn period. We recently demonstrated in adult rats that, in contrast...