Jarno Hoekman
Overview
Explore the profile of Jarno Hoekman including associated specialties, affiliations and a list of published articles.
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36
Citations
414
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Recent Articles
1.
Revel M, Groh K, Bertoli J, Degeratu M, Fischer M, Fischer S, et al.
Environ Toxicol Chem
. 2025 Jan;
PMID: 39880375
Given the need to reduce animal testing for environmental risk assessment, we aim to develop a fish invitrome, an alternative fish modular framework capable of predicting chemical toxicity in fish...
2.
van Hattem C, de Jong A, de Groot J, Hoekman J, Broekman K, Sonke G, et al.
BMJ Open
. 2024 Nov;
14(11):e084483.
PMID: 39521472
Objective: The collection of comprehensive data from post-authorisation trials for conditionally authorised anticancer medicines is frequently delayed. This raises questions about the feasibility of post-authorisation randomised controlled trials (RCTs) that...
3.
Zinken J, Pasmooij A, Ederveen A, Hoekman J, Bloem L
Drug Discov Today
. 2024 Oct;
29(12):104213.
PMID: 39428085
An environmental risk assessment (ERA) is mandatory for all applications for marketing authorisation of medicines in the European Union (EU). We investigated stakeholder perspectives on the role of the ERA...
4.
Kienhuis A, Krul C, van Engelen J, Evelo C, Hessel E, Hoekman J, et al.
ALTEX
. 2024 Oct;
42(1):111-120.
PMID: 39396389
The Virtual Human Platform for Safety Assessment (VHP4Safety) project aims to build a virtual human platform (VHP) to protect human health and revolutionize the safety assessment of chemicals and pharmaceuticals...
5.
Hoogstraaten M, Vriend J, De Leeuw V, Negro S, Moors E, Kienhuis A, et al.
Arch Toxicol
. 2024 Oct;
99(1):43-56.
PMID: 39365316
This perspective paper, which is the result of a collaborative effort between toxicologists and scholars in innovation and transition studies, presents a heuristic framework based on innovation system literature for...
6.
Leufkens H, Kusynova Z, Aitken M, Hoekman J, Stolk P, Klein K, et al.
Drug Discov Today
. 2022 Apr;
27(8):2252-2260.
PMID: 35364271
The future of medicines is likely determined by an array of scientific, socioeconomic, policy, medical need, and geopolitical factors, with many uncertainties ahead. Here, we report from a scenario project,...
7.
Ten Ham R, Frederix G, Wu O, Goettsch W, Leufkens H, Klungel O, et al.
Value Health
. 2022 Mar;
25(3):390-399.
PMID: 35227451
Objectives: Advanced therapy medicinal products (ATMPs) are highly innovative therapies. Their costs and uncertain value claims have raised concerns among health technology assessment (HTA) bodies and payers. Little is known...
8.
Bloem L, Bot R, Mantel-Teeuwisse A, van der Elst M, Sonke G, Klungel O, et al.
Br J Clin Pharmacol
. 2021 Nov;
88(5):2169-2179.
PMID: 34779004
Aims: Cancer drugs are increasingly approved through expedited regulatory pathways including the European conditional marketing authorization (CMA). Whether, when taking CMA post-approval confirmatory trials into account, the level of evidence...
9.
Bloem L, Karomi M, Hoekman J, van der Elst M, Leufkens H, Klungel O, et al.
Expert Opin Drug Saf
. 2021 Jul;
20(11):1433-1442.
PMID: 34263667
Prior studies investigated regulatory actions that reflected a negative impact on drug risks. We aimed to evaluate occurrence of regulatory actions that reflected a negative or positive impact on benefits...
10.
Signals from the Dutch national spontaneous reporting system: Characteristics and regulatory actions
van Hunsel F, de Jong E, Gross-Martirosyan L, Hoekman J
Pharmacoepidemiol Drug Saf
. 2021 Apr;
30(8):1115-1122.
PMID: 33840136
Purpose: The aim of the study is to characterise safety signals based on the Dutch spontaneous reporting system (SRS) and to investigate the association between signal characteristics and Product Information...