Jared O Kafader
Overview
Explore the profile of Jared O Kafader including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
345
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Recent Articles
1.
A Robust and Automated Platform for Charge Detection Mass Spectrometry of Megadalton Biotherapeutics
Janisse S, Fellers R, Raab S, Goodwin M, Bowen K, Lian Z, et al.
Anal Chem
. 2025 Feb;
97(8):4549-4555.
PMID: 39967556
Gene therapies based on adeno-associated viruses are an emerging area with high potential to improve human health. Current quality control techniques to assess contaminates and byproducts from the adeno-associated virus...
2.
Su P, McGee J, Hollas M, Fellers R, Durbin K, Greer J, et al.
Nat Protoc
. 2025 Jan;
PMID: 39747675
Individual ion mass spectrometry (IMS) is the Orbitrap-based extension of the niche mass spectrometry technique known as charge detection mass spectrometry (CDMS). While traditional CDMS analysis is performed on in-house-built...
3.
Des Soye B, McGee J, Hollas M, Forte E, Fellers R, Melani R, et al.
Anal Chem
. 2024 Aug;
PMID: 39143757
Charge detection mass spectrometry (CDMS) is a well-established technique that provides direct mass spectral outputs regardless of analyte heterogeneity or molecular weight. Over the past few years, it has been...
4.
Su P, Hollas M, Butun F, Kanchustambham V, Rubakhin S, Ramani N, et al.
J Proteome Res
. 2024 Mar;
23(6):1883-1893.
PMID: 38497708
We introduce single cell Proteoform imaging Mass Spectrometry (), which realizes the benefit of direct solvent extraction and MS detection of intact proteins from single cells dropcast onto glass slides....
5.
Precise Readout of MEK1 Proteoforms upon MAPK Pathway Modulation by Individual Ion Mass Spectrometry
Drown B, Gupta R, McGee J, Hollas M, Hergenrother P, Kafader J, et al.
Anal Chem
. 2024 Mar;
96(11):4455-4462.
PMID: 38458998
The functions of proteins bearing multiple post-translational modifications (PTMs) are modulated by their modification patterns, yet precise characterization of them is difficult. MEK1 (also known as MAP2K1) is one such...
6.
Goodwin M, Grinfeld D, Yip P, Bowen K, Kafader J, Kelleher N, et al.
J Am Soc Mass Spectrom
. 2024 Jan;
35(4):658-662.
PMID: 38286823
The quality of data in charge detection mass spectrometry depends on accurate determination of ion charge. While the method of selective temporal overview of resonant ions (STORI) has proven to...
7.
McGee J, Su P, Durbin K, Hollas M, Bateman N, Maxwell G, et al.
Nat Commun
. 2023 Dec;
14(1):7946.
PMID: 38040721
No abstract available.
8.
Stiving A, Foreman D, VanAernum Z, Durr E, Wang S, Vlasak J, et al.
J Am Soc Mass Spectrom
. 2023 Nov;
35(1):62-73.
PMID: 38032172
Surface-embedded glycoproteins, such as the spike protein trimers of coronaviruses MERS, SARS-CoV, and SARS-CoV-2, play a key role in viral function and are the target antigen for many vaccines. However,...
9.
Fisher N, McGee J, Bowen K, Goodwin M, Senko M, Kelleher N, et al.
J Am Soc Mass Spectrom
. 2023 Nov;
34(12):2625-2629.
PMID: 38011219
Collision cross section (CCS) measurements determined by ion mobility spectrometry (IMS) provide useful information about gas-phase protein structure that is complementary to mass analysis. Methods for determining CCS without a...
10.
McGee J, Su P, Durbin K, Hollas M, Bateman N, Maxwell G, et al.
Nat Commun
. 2023 Oct;
14(1):6478.
PMID: 37838706
The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion MS based multiplexed workflow for top-down...