Jared A Shadish
Overview
Explore the profile of Jared A Shadish including associated specialties, affiliations and a list of published articles.
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11
Citations
341
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Recent Articles
1.
Nealy E, Reed S, Adelmund S, Badeau B, Shadish J, Girard E, et al.
Bioeng Transl Med
. 2024 Nov;
9(5):e10668.
PMID: 39553428
Hydrogels are extensively employed in healthcare due to their adaptable structures, high water content, and biocompatibility, with FDA-approved applications ranging from spinal cord regeneration to local therapeutic delivery. However, clinical...
2.
Shadish J, Lee J
Biophys Chem
. 2024 Jan;
307:107191.
PMID: 38290242
Intracellular aggregation of transactive response DNA binding protein of 43 kDa (TDP-43) is a hallmark of neurodegenerative diseases such as amyotrophic lateral sclerosis. While primarily a nuclear protein, TDP-43 translocates...
3.
Nealy E, Reed S, Adelmund S, Badeau B, Shadish J, Girard E, et al.
bioRxiv
. 2023 Sep;
PMID: 37693598
Hydrogels generally have broad utilization in healthcare due to their tunable structures, high water content, and inherent biocompatibility. FDA-approved applications of hydrogels include spinal cord regeneration, skin fillers, and local...
4.
McGlinchey R, Ni X, Shadish J, Jiang J, Lee J
Proc Natl Acad Sci U S A
. 2021 Aug;
118(35).
PMID: 34452994
The generation of α-synuclein (α-syn) truncations from incomplete proteolysis plays a significant role in the pathogenesis of Parkinson's disease. It is well established that C-terminal truncations exhibit accelerated aggregation and...
5.
Liu L, Shadish J, Arakawa C, Shi K, Davis J, DeForest C
Adv Biosyst
. 2021 Jul;
2(12).
PMID: 34316509
Although mechanical signals presented by the extracellular matrix are known to regulate many essential cell functions, the specific effects of these interactions, particularly in response to dynamic and heterogeneous cues,...
6.
Farahani P, Adelmund S, Shadish J, DeForest C
J Mater Chem B
. 2020 Apr;
5(23):4435-4442.
PMID: 32263971
Click chemistry has proved a valuable tool in biocompatible hydrogel formation for 3D cell culture, owing to its bioorthogonal nature and high efficiency under physiological conditions. While traditional click reactions...
7.
Shadish J, Strange A, DeForest C
J Am Chem Soc
. 2019 Sep;
141(39):15619-15625.
PMID: 31525979
Given the critical role that proteins play in almost all biological processes, there is great interest in controlling their presentation within and release from biomaterials. Despite such outstanding enthusiasm, previously...
8.
Gawade P, Shadish J, Badeau B, DeForest C
Adv Mater
. 2019 Jul;
31(33):e1902462.
PMID: 31265196
The controlled presentation of proteins from and within materials remains of significant interest for many bioengineering applications. Though "smart" platforms offer control over protein release in response to a single...
9.
Shadish J, Benuska G, DeForest C
Nat Mater
. 2019 May;
18(9):1005-1014.
PMID: 31110347
Protein-modified biomaterials can be used to modulate cellular function in three dimensions. However, as the dynamic heterogeneous control over complex cell physiology continues to be sought, strategies that permit a...
10.
Badeau B, Comerford M, Arakawa C, Shadish J, DeForest C
Nat Chem
. 2018 Feb;
10(3):251-258.
PMID: 29461528
The successful transport of drug- and cell-based therapeutics to diseased sites represents a major barrier in the development of clinical therapies. Targeted delivery can be mediated through degradable biomaterial vehicles...