Janos Groh
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Explore the profile of Janos Groh including associated specialties, affiliations and a list of published articles.
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39
Citations
657
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Recent Articles
1.
Groh J, Simons M
Neuron
. 2024 Nov;
113(1):127-139.
PMID: 39541972
Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase in white matter hyperintensities. These changes are closely linked...
2.
Yasa S, Butz E, Colombo A, Chandrachud U, Montore L, Tschirner S, et al.
Commun Biol
. 2024 Oct;
7(1):1373.
PMID: 39438652
Loss-of-function mutations in CLN3 cause juvenile Batten disease, featuring neurodegeneration and early-stage neuroinflammation. How loss of CLN3 function leads to early neuroinflammation is not yet understood. Here, we have comprehensively...
3.
Horner M, Popp S, Branchu J, Stevanin G, Darios F, Klebe S, et al.
Front Neurosci
. 2024 Mar;
18:1299554.
PMID: 38435059
We have previously demonstrated that neuroinflammation by the adaptive immune system acts as a robust and targetable disease amplifier in a mouse model of Spastic Paraplegia, type 11 (SPG11), a...
4.
McFleder R, Makhotkina A, Groh J, Keber U, Imdahl F, Pena Mosca J, et al.
Nat Commun
. 2023 Nov;
14(1):7529.
PMID: 37981650
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson's disease (PD). One trigger of the immune system in PD is aggregation of...
5.
Groh J, Abdelwahab T, Kattimani Y, Horner M, Loserth S, Gudi V, et al.
Nat Commun
. 2023 Oct;
14(1):6911.
PMID: 37903797
Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and...
6.
Abdelwahab T, Stadler D, Knopper K, Arampatzi P, Saliba A, Kastenmuller W, et al.
iScience
. 2023 May;
26(5):106698.
PMID: 37182098
Myelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by...
7.
Groh J, Knopper K, Arampatzi P, Yuan X, Losslein L, Saliba A, et al.
Nat Aging
. 2023 Apr;
1(4):357-367.
PMID: 37117598
Aging is a major risk factor for the development of nervous system functional decline, even in the absence of diseases or trauma. The axon-myelin units and synaptic terminals are some...
8.
Gottle P, Groh J, Reiche L, Gruchot J, Rychlik N, Werner L, et al.
J Neuroinflammation
. 2023 Jan;
20(1):7.
PMID: 36611185
Background: Promotion of myelin repair in the context of demyelinating diseases such as multiple sclerosis (MS) still represents a clinical unmet need, given that this disease is not only characterized...
9.
Kaya T, Mattugini N, Liu L, Ji H, Cantuti-Castelvetri L, Wu J, et al.
Nat Neurosci
. 2022 Oct;
25(11):1446-1457.
PMID: 36280798
A hallmark of nervous system aging is a decline of white matter volume and function, but the underlying mechanisms leading to white matter pathology are unknown. In the present study,...
10.
Horner M, Groh J, Klein D, Ilg W, Schols L, Santos S, et al.
Exp Neurol
. 2022 May;
355:114119.
PMID: 35605667
Pharmacological targeting of neuroinflammation in distinct models of genetically mediated disorders of the central nervous system (CNS) has been shown to attenuate disease outcome significantly. These include mouse models mimicking...