Janneke Wit
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Explore the profile of Janneke Wit including associated specialties, affiliations and a list of published articles.
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20
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323
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Recent Articles
1.
Shaver A, Miller I, Schaye E, Moya N, Collins J, Wit J, et al.
PLoS Pathog
. 2024 May;
20(5):e1012245.
PMID: 38768235
Albendazole (a benzimidazole) and ivermectin (a macrocyclic lactone) are the two most commonly co-administered anthelmintic drugs in mass-drug administration programs worldwide. Despite emerging resistance, we do not fully understand the...
2.
Shaver A, Miller I, Schaye E, Moya N, Collins J, Wit J, et al.
bioRxiv
. 2024 Feb;
PMID: 38370666
Albendazole and ivermectin are the two most commonly co-administered anthelmintic drugs in mass-drug administration programs worldwide. Despite emerging resistance, we do not fully understand the mechanisms of resistance to these...
3.
Wit J, Dilks C, Zhang G, Kim Guisbert K, Zdraljevic S, Guisbert E, et al.
PLoS One
. 2023 Aug;
18(8):e0286473.
PMID: 37561720
Anthelmintic drugs are used to treat parasitic roundworm and flatworm infections in humans and other animals. Caenorhabditis elegans is an established model to investigate anthelmintics used to treat roundworms. In...
4.
Shaver A, Wit J, Dilks C, Crombie T, Li H, Aroian R, et al.
PLoS Pathog
. 2023 Apr;
19(4):e1011285.
PMID: 37011090
Treatment of parasitic nematode infections in humans and livestock relies on a limited arsenal of anthelmintic drugs that have historically reduced parasite burdens. However, anthelmintic resistance (AR) is increasing, and...
5.
Wit J, Workentine M, Redman E, Laing R, Stevens L, Cotton J, et al.
Int J Parasitol
. 2022 Sep;
52(10):677-689.
PMID: 36113620
Genome-wide methods offer a powerful approach to detect signatures of drug selection. However, limited availability of suitable reference genomes and the difficulty of obtaining field populations with well-defined, distinct drug...
6.
Beaumelle C, Redman E, de Rijke J, Wit J, Benabed S, Debias F, et al.
Parasit Vectors
. 2021 Dec;
14(1):594.
PMID: 34863264
Background: Gastrointestinal nematodes are ubiquitous for both domestic and wild ungulates and have varying consequences for health and fitness. They exist as complex communities of multiple co-infecting species, and we...
7.
Wit J, Rodriguez B, Andersen E
Int J Parasitol Drugs Drug Resist
. 2021 Apr;
16:1-8.
PMID: 33878514
Treatment of parasitic nematode infections depends primarily on the use of anthelmintics. However, this drug arsenal is limited, and resistance against most anthelmintics is widespread. Emodepside is a new anthelmintic...
8.
Evans K, Wit J, Stevens L, Hahnel S, Rodriguez B, Park G, et al.
PLoS Pathog
. 2021 Mar;
17(3):e1009297.
PMID: 33720993
Parasitic nematodes cause a massive worldwide burden on human health along with a loss of livestock and agriculture productivity. Anthelmintics have been widely successful in treating parasitic nematodes. However, resistance...
9.
Wit J, Dilks C, Andersen E
Trends Parasitol
. 2020 Dec;
37(3):240-250.
PMID: 33317926
Anthelmintic drugs are the major line of defense against parasitic nematode infections, but the arsenal is limited and resistance threatens sustained efficacy of the available drugs. Discoveries of the modes...
10.
Doyle S, Tracey A, Laing R, Holroyd N, Bartley D, Bazant W, et al.
Commun Biol
. 2020 Nov;
3(1):656.
PMID: 33168940
Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-specific traits among...