Janice E Clements
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Explore the profile of Janice E Clements including associated specialties, affiliations and a list of published articles.
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94
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3053
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Recent Articles
11.
Abreu C, Veenhuis R, Avalos C, Graham S, Parrilla D, Ferreira E, et al.
mBio
. 2019 Aug;
10(4).
PMID: 31431552
Human immunodeficiency virus (HIV) eradication or long-term suppression in the absence of antiretroviral therapy (ART) requires an understanding of all viral reservoirs that could contribute to viral rebound after ART...
12.
Bender A, Simonetti F, Kumar M, Fray E, Bruner K, Timmons A, et al.
Cell Host Microbe
. 2019 Jul;
26(1):73-85.e4.
PMID: 31295427
Evaluation of HIV cure strategies is complicated by defective proviruses that persist in ART-treated patients but are irrelevant to cure. Non-human primates (NHP) are essential for testing cure strategies. However,...
13.
Abreu C, Veenhuis R, Avalos C, Graham S, Queen S, Shirk E, et al.
J Virol
. 2019 May;
93(15).
PMID: 31118264
Understanding the cellular and anatomical sites of latent virus that contribute to human immunodeficiency virus (HIV) rebound is essential for eradication. In HIV-positive patients, CD4 T lymphocytes comprise a well-defined...
14.
Veenhuis R, Clements J, Gama L
Curr HIV/AIDS Rep
. 2019 Feb;
16(1):96-104.
PMID: 30734905
Purpose Of Review: In addition to preventive protocols and antiretroviral therapy, HIV-1 eradication has been considered as an additional strategy to help fight the AIDS epidemic. With the support of...
15.
Williams D, Askew L, Jones E, Clements J
J Immunol
. 2018 Dec;
202(1):105-118.
PMID: 30504423
An integral component of the antiviral response, type I IFNs require regulation to modulate immune activation. We identify β-arrestin 2 as a key modulator of type I IFN in primary...
16.
Abreu C, Shirk E, Queen S, Mankowski J, Gama L, Clements J
J Neuroimmune Pharmacol
. 2018 Sep;
14(1):23-32.
PMID: 30167896
Lentiviruses are retroviruses that primarily infect myeloid cells, leading to acute inflammatory infections in many tissues particularly, lung, joints and the central nervous system (CNS). Acute infection by lentiviruses is...
17.
Veenstra M, Byrd D, Inglese M, Buyukturkoglu K, Williams D, Fleysher L, et al.
J Neuroimmune Pharmacol
. 2018 Jul;
14(1):120-133.
PMID: 29981000
HIV-associated neurocognitive disorders (HAND) occur in ~50% of HIV infected individuals despite combined antiretroviral therapy. Transmigration into the CNS of CD14CD16 monocytes, particularly those that are HIV infected and express...
18.
Gama L, Abreu C, Shirk E, Queen S, Beck S, Metcalf Pate K, et al.
Curr Top Microbiol Immunol
. 2018 May;
417:111-130.
PMID: 29770863
Lentiviruses infect myeloid cells, leading to acute infection followed by persistent/latent infections not cleared by the host immune system. HIV and SIV are lentiviruses that infect CD4+ lymphocytes in addition...
19.
Mangus L, Beck S, Queen S, Brill S, Shirk E, Metcalf Pate K, et al.
Am J Pathol
. 2017 Dec;
188(1):125-134.
PMID: 29229308
A retrospective neuropathologic review of 30 SIV-infected pigtailed macaques receiving combination antiretroviral therapy (cART) was conducted. Seventeen animals with lymphocyte-dominant inflammation in the brain and/or meninges that clearly was morphologically...
20.
Veenstra M, Leon-Rivera R, Li M, Gama L, Clements J, Berman J
mBio
. 2017 Oct;
8(5).
PMID: 29066542
HIV reservoirs persist despite antiretroviral therapy (ART) and are established within a few days after infection. Infected myeloid cells in the central nervous system (CNS) may contribute to the establishment...