Janet D Klein
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Explore the profile of Janet D Klein including associated specialties, affiliations and a list of published articles.
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118
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2526
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Recent Articles
1.
Wang Y, LaRocque L, Ruiz J, Rodriguez E, Sands J, Klein J
Biomedicines
. 2023 Jul;
11(7).
PMID: 37509484
Hyponatremia (hypo-osmolality) is a disorder of water homeostasis due to abnormal renal diluting capacity. The body limits the degree to which serum sodium concentration falls through a mechanism called "vasopressin...
2.
Wang Y, Klein J, Sands J
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047509
We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A)...
3.
Huang Y, Yu M, Kuma A, Klein J, Wang Y, Hassounah F, et al.
Front Physiol
. 2021 Sep;
12:697139.
PMID: 34489723
Background: Our previous study found that acupuncture with low frequency electrical stimulation (Acu/LFES) prevents muscle atrophy by attenuation of protein degradation in mice. The current study examines the impact of...
4.
Klein J, Khanna I, Pillarisetti R, Hagan R, LaRocque L, Rodriguez E, et al.
JCI Insight
. 2021 Mar;
6(8).
PMID: 33724959
Nephrogenic diabetes insipidus (NDI) patients produce large amounts of dilute urine. NDI can be congenital, resulting from mutations in the type-2 vasopressin receptor (V2R), or acquired, resulting from medications such...
5.
Kovarik J, Morisawa N, Wild J, Marton A, Takase-Minegishi K, Minegishi S, et al.
Acta Physiol (Oxf)
. 2021 Feb;
232(1):e13629.
PMID: 33590667
Aim: We have reported earlier that a high salt intake triggered an aestivation-like natriuretic-ureotelic body water conservation response that lowered muscle mass and increased blood pressure. Here, we tested the...
6.
Ma F, Chen G, Rodriguez E, Klein J, Sands J, Wang Y
Cells
. 2020 Dec;
9(12).
PMID: 33255239
Adrenomedullin (ADM) is a vasodilator that causes natriuresis and diuresis. However, the direct effect of ADM on osmotic water permeability in the rat inner medullary collecting duct (IMCD) has not...
7.
Chen S, Feng X, Chen X, Zhuang Z, Xiao J, Fu H, et al.
Am J Physiol Renal Physiol
. 2020 May;
319(1):F52-F62.
PMID: 32463725
14-3-3γ is a small protein regulating its target proteins through binding to phosphorylated serine/threonine residues. Sequence analysis of large-conductance Ca-activated K (BK) channels revealed a putative 14-3-3 binding site in...
8.
Kuma A, Wang X, Klein J, Tan L, Naqvi N, Rianto F, et al.
FASEB J
. 2020 May;
34(6):8296-8309.
PMID: 32367640
Uremic cardiomyopathy, characterized by hypertension, cardiac hypertrophy, and fibrosis, is a complication of chronic kidney disease (CKD). Urea transporter (UT) inhibition increases the excretion of water and urea, but the...
9.
Wang Y, Ma F, Rodriguez E, Klein J, Sands J
Cells
. 2020 Apr;
9(4).
PMID: 32295252
Aldosterone indirectly regulates water reabsorption in the distal tubule by regulating sodium reabsorption. However, the direct effect of aldosterone on vasopressin-regulated water and urea permeability in the rat inner medullary...
10.
Rianto F, Kuma A, Ellis C, Hassounah F, Rodriguez E, Wang X, et al.
Am J Physiol Renal Physiol
. 2020 Mar;
318(5):F1160-F1166.
PMID: 32174141
Renal fibrosis is a major contributor to the development and progression of chronic kidney disease. A low-protein diet can reduce the progression of chronic kidney disease and reduce the development...