Jana Mandikova
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Explore the profile of Jana Mandikova including associated specialties, affiliations and a list of published articles.
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20
Citations
154
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Recent Articles
1.
Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, et al.
Br J Pharmacol
. 2016 Feb;
173(10):1703-15.
PMID: 26920453
Background And Purpose: The organic cation transporter 1 (OCT1) transports cationic drugs into hepatocytes. The high hepatic expression of OCT1 is controlled by the HNF4α and USF transcription factors. Pregnane...
2.
Mandikova J, Volkova M, Pavek P, Navratilova L, Hyrsova L, Janeba Z, et al.
Front Pharmacol
. 2016 Jan;
6:304.
PMID: 26779022
Entecavir (ETV) is one of the most potent agents for the treatment of the hepatitis B viral infection. The drug is principally eliminated by the kidney. The goal of this...
3.
Paraskevopoulos G, Kratky M, Mandikova J, Trejtnar F, Stolarikova J, Pavek P, et al.
Bioorg Med Chem
. 2015 Nov;
23(22):7292-301.
PMID: 26526729
Inspired by the high antituberculous activity of novel nitro-substituted derivatives and based on promising predicted ADMET properties we have synthesized a series of 33 salicylanilides containing nitro-group in their salicylic...
4.
Volkova M, Mandikova J, Barta P, Navratilova L, Laznickova A, Trejtnar F
J Labelled Comp Radiopharm
. 2015 Nov;
58(13-14):483-9.
PMID: 26526343
In vivo metabolism of the radiolabelled receptor-specific peptides has been described; however, information regarding the pharmacokinetic behaviour of the degradation products within the body is very scarce. The present study...
5.
Servusova-Vanaskova B, Paterova P, Garaj V, Mandikova J, Kunes J, Naesens L, et al.
Chem Biol Drug Des
. 2015 Feb;
86(4):674-81.
PMID: 25676890
This work presents synthesis and antimicrobial evaluation of nineteen 6-alkylamino-N-phenylpyrazine-2-carboxamides. Antimycobacterial activity was determined against Mycobacterium tuberculosis H37Rv, M. kansasii and two strains of M. avium. Generally, the antimycobacterial activity...
6.
Zitko J, Servusova B, Janoutova A, Paterova P, Mandikova J, Garaj V, et al.
Bioorg Med Chem
. 2014 Dec;
23(1):174-83.
PMID: 25438883
Substitution of chlorine in 5-chloro-N-phenylpyrazine-2-carboxamide (1) with simple n-alkylamines yielded a series of 5-alkylamino-N-phenylpyrazine-2-carboxamides (propylamino to octylamino derivatives), which possessed similar or increased activity against Mycobacterium tuberculosis H37Rv compared to...
7.
Trejtnar F, Mandikova J, Kocincova J, Volkova M
Antimicrob Agents Chemother
. 2014 Jun;
58(10):5650-7.
PMID: 24957831
Amphotericin B (AmB) is excreted via the renal excretion route. This excretion process may result in nephrotoxicity. However, relevant information on the precise renal excretion mechanisms is not available. The...
8.
Novy Z, Laznickova A, Mandikova J, Barta P, Laznicek M, Trejtnar F
J Labelled Comp Radiopharm
. 2014 Jun;
57(7):448-52.
PMID: 24889367
Monoclonal antibodies are used in the therapy of various diseases. Thanks to their high specific uptake in target tissues, these antibodies can be utilized in targeted radioimmunotherapy as carriers of...
9.
Servusova B, Paterova P, Mandikova J, Kubicek V, Kucera R, Kunes J, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(2):450-3.
PMID: 24388809
A series of pyrazinamide derivatives with alkylamino substitution was designed, synthesized and tested for their ability to inhibit the growth of selected mycobacterial, bacterial and fungal strains. The target structures...
10.
Vinsova J, Kozic J, Kratky M, Stolarikova J, Mandikova J, Trejtnar F, et al.
Bioorg Med Chem
. 2013 Dec;
22(2):728-37.
PMID: 24369840
A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis,...