Jana K Shirey
Overview
Explore the profile of Jana K Shirey including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
438
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0
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Recent Articles
1.
Digby G, Shirey J, Conn P
Mol Biosyst
. 2010 Jun;
6(8):1345-54.
PMID: 20582339
Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the treatment of multiple CNS disorders. The high degree of conservation of amino acids comprising the orthosteric acetylcholine (ACh) binding site...
2.
Shirey J, Brady A, Jones P, Davis A, Bridges T, Kennedy J, et al.
J Neurosci
. 2009 Nov;
29(45):14271-86.
PMID: 19906975
M(1) muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a major limitation to testing this hypothesis has been a lack...
3.
Kennedy J, Bridges T, Gentry P, Brogan J, Kane A, Jones C, et al.
ChemMedChem
. 2009 Aug;
4(10):1600-7.
PMID: 19705385
No abstract available.
4.
Marlo J, Niswender C, Days E, Bridges T, Xiang Y, Rodriguez A, et al.
Mol Pharmacol
. 2008 Dec;
75(3):577-88.
PMID: 19047481
Activators of M(1) muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the development of M(1)-active compounds has resulted in nonselective activation of the highly...
5.
Brady A, Jones C, Bridges T, Kennedy J, Thompson A, Heiman J, et al.
J Pharmacol Exp Ther
. 2008 Sep;
327(3):941-53.
PMID: 18772318
Previous clinical and animal studies suggest that selective activators of M(1) and/or M(4) muscarinic acetylcholine receptors (mAChRs) have potential as novel therapeutic agents for treatment of schizophrenia and Alzheimer's disease....
6.
Shirey J, Xiang Z, Orton D, Brady A, Johnson K, Williams R, et al.
Nat Chem Biol
. 2007 Dec;
4(1):42-50.
PMID: 18059262
Muscarinic acetylcholine receptors (mAChRs) provide viable targets for the treatment of multiple central nervous system disorders. We have used cheminformatics and medicinal chemistry to develop new, highly selective M4 allosteric...