Jan Wouter Drijfhout
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Explore the profile of Jan Wouter Drijfhout including associated specialties, affiliations and a list of published articles.
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66
Citations
2783
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Recent Articles
1.
Linthorst N, Jongejan Y, Dirven R, Laan S, Bierings R, Casari C, et al.
Blood Adv
. 2025 Jan;
9(2):310-320.
PMID: 39820471
Treatment options for the bleeding disorder von Willebrand disease type 2B (VWD2B) are insufficient and fail to address the negative effects of circulating mutant von Willebrand factor (VWF). The dominant-negative...
2.
Bouhrour N, van der Reijden T, Voet M, Schonkeren-Ravensbergen B, Cordfunke R, Drijfhout J, et al.
Antibiotics (Basel)
. 2023 Dec;
12(12).
PMID: 38136778
The antibiotic management of catheter-related infections (CRIs) often fails owing to the emergence of antimicrobial-resistant strains and/or biofilm/persister apparitions. Thus, we investigated the efficacy of two novel antimicrobial agents, i.e.,...
3.
van Gent M, Klodzinska S, Drijfhout J, Nielsen H, Nibbering P
Eur J Pharm Biopharm
. 2023 Nov;
193:254-261.
PMID: 37944710
Antimicrobial peptides (AMPs) are promising alternatives to antibiotics for treatment of antimicrobial resistant (AMR) bacterial infections. However, their narrow therapeutic window due to in vivo toxicity and limited stability hampers...
4.
van Gent M, Schonkeren-Ravensbergen B, Achkif A, Beentjes D, Dolezal N, van Meijgaarden K, et al.
J Innate Immun
. 2023 Sep;
15(1):724-738.
PMID: 37725929
Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant bacteria without inducing resistance; however, challenges...
5.
On A, Vejzovic D, Jennings J, Parigger L, Cordfunke R, Drijfhout J, et al.
Antibiotics (Basel)
. 2023 Jul;
12(7).
PMID: 37508259
OP-145 and SAAP-148, two 24-mer antimicrobial peptides derived from human cathelicidin LL-37, exhibit killing efficacy against both Gram-positive and Gram-negative bacteria at comparable peptide concentrations. However, when it comes to...
6.
van Gent M, Klodzinska S, Severin M, Ali M, van Doodewaerd B, Bos E, et al.
Nanomedicine
. 2023 Jul;
52:102694.
PMID: 37394107
No abstract available.
7.
van der Wulp W, Gram A, Bleijlevens B, Hagedoorn R, Araman C, Kim R, et al.
Front Immunol
. 2023 Jun;
14:1183914.
PMID: 37261346
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to...
8.
Bournez C, Riool M, de Boer L, Cordfunke R, de Best L, van Leeuwen R, et al.
Antibiotics (Basel)
. 2023 Apr;
12(4).
PMID: 37107088
To combat infection by microorganisms host organisms possess a primary arsenal via the innate immune system. Among them are defense peptides with the ability to target a wide range of...
9.
van Gent M, van Baaren T, Klodzinska S, Ali M, Dolezal N, van Doodewaerd B, et al.
Pharmaceutics
. 2023 Feb;
15(2).
PMID: 36839751
Chronic wound infections colonized by bacteria are becoming more difficult to treat with current antibiotics due to the development of antimicrobial resistance (AMR) as well as biofilm and persister cell...
10.
Ali M, van Gent M, de Waal A, van Doodewaerd B, Bos E, Koning R, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36769188
Synthetic antimicrobial and antibiofilm peptide (SAAP-148) commits significant antimicrobial activities against antimicrobial resistant (AMR) planktonic bacteria and biofilms. However, SAAP-148 is limited by its low selectivity index, i.e., ratio between...