Jan M Woynarowski
Overview
Explore the profile of Jan M Woynarowski including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
141
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Recent Articles
1.
Woynarowski J, Krugliak M, Ginsburg H
Mol Biochem Parasitol
. 2007 May;
154(1):70-81.
PMID: 17524501
Unlabelled: Human malaria parasites, including the most lethal Plasmodium falciparum, are increasingly resistant to existing antimalarial drugs. One remarkable opportunity to selectively target P. falciparum stems from the unique AT-richness...
2.
Trevino A, Woynarowska B, Herman T, Priebe W, Woynarowski J
Mol Cancer Ther
. 2004 Nov;
3(11):1403-10.
PMID: 15542779
Targeting topoisomerase II (topo II) is regarded as an important component of the pleiotropic mechanism of action of anthracycline drugs. Here, we show that 4-demethoxy analogues of doxorubicin, including annamycin,...
3.
Liang H, Salinas R, Leal B, Kosakowska-Cholody T, Michejda C, Waters S, et al.
Mol Cancer Ther
. 2004 Nov;
3(11):1385-96.
PMID: 15542777
Irofulven (hydroxymethylacylfulvene) is a novel antitumor drug, which acts by alkylating cellular macromolecular targets. The drug is a potent inducer of apoptosis in various types of tumor cells, whereas it...
4.
Woynarowski J, Woynarowska B, Trevino A, Salinas R, Herman T, Waters S, et al.
Cancer Biol Ther
. 2004 Oct;
3(11):1137-42.
PMID: 15467441
Unlike postmitotic cell death, direct premitotic apoptosis diminishes the risk of clonal selection and allows for the elimination of slowly growing cancer cells. This study characterized the ability to induce...
5.
Woynarowski J
Curr Cancer Drug Targets
. 2004 Mar;
4(2):219-34.
PMID: 15032671
The human genome contains a unique class of domains, referred to as AT islands, which consist typically of 200-1000 bp long tracts of up to 100% A/T DNA. The significance...
6.
Jackson J, Trevino A, Herzig M, Herman T, Woynarowski J
Nucleic Acids Res
. 2003 Oct;
31(21):6354-64.
PMID: 14576323
AT-rich minisatellites (AT islands) are sites of genomic instability in cancer cells and targets for extremely lethal AT-specific drugs, such as bizelesin. Here we investigated the AT islands in the...
7.
Faivre S, Chan D, Salinas R, Woynarowska B, Woynarowski J
Biochem Pharmacol
. 2003 Jun;
66(2):225-37.
PMID: 12826265
Platinum anticancer drugs, such as cisplatin, are thought to exert their activity by DNA damage. Oxaliplatin, a clinically active diaminocyclohexane platinum compound, however, requires fewer DNA-Pt adducts than cisplatin to...
8.
Herzig M, Trevino A, Liang H, Salinas R, Waters S, Macdonald J, et al.
Biochem Pharmacol
. 2003 Feb;
65(4):503-13.
PMID: 12566077
The overexpression of Bcl-2 is implicated in the resistance of cancer cells to apoptosis. This study explored the potential of irofulven (hydroxymethylacylfulvene, HMAF, MGI 114, NSC 683863), a novel DNA-...
9.
Woynarowska B, Woynarowski J
Biochim Biophys Acta
. 2002 Jun;
1587(2-3):309-17.
PMID: 12084473
Elimination of cancer cells by early apoptosis is preferred over other forms of cell growth inhibition. Apoptosis directly leads to tumor regression and reduces risks of selecting more aggressive and/or...
10.
Woynarowski J
Biochim Biophys Acta
. 2002 Jun;
1587(2-3):300-8.
PMID: 12084472
Cellular DNA is not a uniform target for DNA-reactive drugs. At the nucleotide level, drugs recognize and bind short motifs of a few base pairs. The location of drug adducts...