Jan Krumsiek
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Explore the profile of Jan Krumsiek including associated specialties, affiliations and a list of published articles.
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128
Citations
5193
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Recent Articles
1.
Arnold M, Buyukozkan M, Doraiswamy P, Nho K, Wu T, Gudnason V, et al.
Nat Commun
. 2025 Feb;
16(1):1910.
PMID: 39994231
Impaired glucose uptake in the brain is an early presymptomatic manifestation of Alzheimer's disease (AD), with symptom-free periods of varying duration that likely reflect individual differences in metabolic resilience. We...
2.
Neth B, Huynh K, Giles C, Wang T, Mellett N, Duong T, et al.
Commun Med (Lond)
. 2025 Jan;
5(1):11.
PMID: 39779882
Background: Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset and progression. Although previous studies have suggested that certain diets...
3.
Al-Ishaq R, Ferrara C, Stephan N, Krumsiek J, Suhre K, Montrose D
Metabolites
. 2024 Dec;
14(12).
PMID: 39728487
Nutritional metabolomics provides a comprehensive overview of the biochemical processes that are induced by dietary intake through the measurement of metabolite profiles in biological samples. However, there is a lack...
4.
Batra R, Krumsiek J, Wang X, Allen M, Blach C, Kastenmuller G, et al.
Alzheimers Dement
. 2024 Oct;
20(12):8294-8307.
PMID: 39439201
Background: Metabolic dysregulation is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD) and progressive supranuclear palsy (PSP). Although metabolic dysregulation is a common link between these two tauopathies, a...
5.
Schweickart A, Chetnik K, Batra R, Kaddurah-Daouk R, Suhre K, Halama A, et al.
Commun Biol
. 2024 Sep;
7(1):1094.
PMID: 39237774
Recent advances in high-throughput measurement technologies have enabled the analysis of molecular perturbations associated with disease phenotypes at the multi-omic level. Such perturbations can range in scale from fluctuations of...
6.
Halama A, Zaghlool S, Thareja G, Kader S, Al Muftah W, Mook-Kanamori M, et al.
Nat Commun
. 2024 Aug;
15(1):7111.
PMID: 39160153
In-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and...
7.
Schweickart A, Batra R, Neth B, Martino C, Shenhav L, Zhang A, et al.
NPJ Metab Health Dis
. 2024 Jul;
2(1):15.
PMID: 38962750
Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including a person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially...
8.
Harada M, Adam J, Covic M, Ge J, Brandmaier S, Muschet C, et al.
Cardiovasc Diabetol
. 2024 Jun;
23(1):199.
PMID: 38867314
Background: Metformin and sodium-glucose-cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for managing hyperglycemia in diabetes. However, their detailed impacts on metabolic processes, particularly within the citric acid (TCA) cycle and its...
9.
Houerbi N, Kim J, Overbey E, Batra R, Schweickart A, Patras L, et al.
Nat Commun
. 2024 Jun;
15(1):4862.
PMID: 38862464
As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from...
10.
Overbey E, Kim J, Tierney B, Park J, Houerbi N, Lucaci A, et al.
Nature
. 2024 Jun;
632(8027):1145-1154.
PMID: 38862028
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space. Yet...