Jan Gruber
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Explore the profile of Jan Gruber including associated specialties, affiliations and a list of published articles.
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65
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1637
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Recent Articles
1.
Pabis K, Barardo D, Gruber J, Sirbu O, Malavolta M, Selvarajoo K, et al.
Ageing Res Rev
. 2024 Sep;
101:102512.
PMID: 39332712
Although lifespan extension remains the gold standard for assessing interventions proposed to impact the biology of aging, there are important limitations to this approach. Our reanalysis of lifespan studies from...
2.
Yusri K, Kumar S, Fong S, Gruber J, Sorrentino V
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928497
Aging is a complex and time-dependent decline in physiological function that affects most organisms, leading to increased risk of age-related diseases. Investigating the molecular underpinnings of aging is crucial to...
3.
Fong S, Pabis K, Latumalea D, Dugersuren N, Unfried M, Tolwinski N, et al.
Nat Aging
. 2024 Jun;
4(8):1137-1152.
PMID: 38898237
Clocks that measure biological age should predict all-cause mortality and give rise to actionable insights to promote healthy aging. Here we applied dimensionality reduction by principal component analysis to clinical...
4.
Raine J, Tolwinski N, Gruber J, Mathuru A
Alzheimers Res Ther
. 2024 Jun;
16(1):123.
PMID: 38849926
Background: Recent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the development of associated pathologies after surgeries with contaminated instruments and...
5.
Pabis K, Barardo D, Sirbu O, Selvarajoo K, Gruber J, Kennedy B
Elife
. 2024 Apr;
12.
PMID: 38567944
Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found...
6.
Kaur P, Otgonbaatar A, Ramamoorthy A, Chua E, Harmston N, Gruber J, et al.
Aging (Albany NY)
. 2022 Oct;
14(20):8270-8291.
PMID: 36287172
Why biological age is a major risk factor for many of the most important human diseases remains mysterious. We know that as organisms age, stem cell pools are exhausted while...
7.
Khanijou J, Yee Z, Raida M, Lee J, Tay E, Gruber J, et al.
J Proteome Res
. 2022 Oct;
21(11):2664-2686.
PMID: 36181456
Protein turnover maintains the proteome's functional integrity. Here, protein turnover efficiency over time in wild-type was assessed using inverse [N]-pulse labeling up to 7 days after the egg-laying phase at...
8.
Unfried M, Ng L, Cazenave-Gassiot A, Batchu K, Kennedy B, Wenk M, et al.
Front Aging
. 2022 Jul;
3:828239.
PMID: 35821819
Complexity is a fundamental feature of biological systems. Omics techniques like lipidomics can simultaneously quantify many thousands of molecules, thereby directly capturing the underlying biological complexity. However, this approach transfers...
9.
Lim D, Chen Y, Ng L, Gruber J, Gan Y
Mol Microbiol
. 2022 Mar;
117(5):1089-1103.
PMID: 35279884
Reduced glutathione (GSH) plays an essential role in relieving oxidative insult from the generation of free radicals via normal physiological processes. However, GSH can be exploited by bacteria as a...
10.
Admasu T, Barardo D, Ng L, Batchu K, Cazenave-Gassiot A, Wenk M, et al.
Geroscience
. 2021 May;
44(2):1029-1046.
PMID: 33988831
In populations around the world, the fraction of humans aged 65 and above is increasing at an unprecedented rate. Aging is the main risk factor for the most important degenerative...