Jan Brughmans
Overview
Explore the profile of Jan Brughmans including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
52
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Recent Articles
1.
Hamouda A, Filtjens J, Brabants E, Kancheva D, Debraekeleer A, Brughmans J, et al.
Nat Commun
. 2024 Dec;
15(1):10635.
PMID: 39639025
Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells...
2.
Clappaert E, Kancheva D, Brughmans J, Debraekeleer A, Bardet P, Elkrim Y, et al.
Front Immunol
. 2023 Aug;
14:1166180.
PMID: 37622122
Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase...
3.
Kiss M, Lebegge E, Murgaski A, Van Damme H, Kancheva D, Brughmans J, et al.
Front Immunol
. 2022 Dec;
13:1003975.
PMID: 36531986
Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation. Infiltration of myeloid cells...
4.
Murgaski A, Kiss M, Van Damme H, Kancheva D, Vanmeerbeek I, Keirsse J, et al.
Cancer Res
. 2022 Aug;
82(20):3785-3801.
PMID: 35979635
Significance: This work highlights the temporal roles of different dendritic cell subsets in promoting CD8+ T-cell-driven responses to CD40 agonist therapy in cancer.
5.
Kiss M, Vande Walle L, Saavedra P, Lebegge E, Van Damme H, Murgaski A, et al.
Cancer Immunol Res
. 2020 Dec;
9(3):309-323.
PMID: 33361087
IL1β is a central mediator of inflammation. Secretion of IL1β typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an...