Jamila Laoukili
Overview
Explore the profile of Jamila Laoukili including associated specialties, affiliations and a list of published articles.
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26
Citations
1302
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Recent Articles
1.
Poghosyan S, Frenkel N, van den Bent L, Raats D, Spaapen T, Laoukili J, et al.
Br J Cancer
. 2024 Nov;
132(1):69-80.
PMID: 39521880
Background: The formation of lung metastasis as part of the progression of colon cancer is a poorly understood process. Theoretically, liver metastases could seed lung metastases. Methods: To assess the...
2.
Kucukkose E, Baars M, Amini M, Schraa S, Floor E, Bol G, et al.
Br J Cancer
. 2023 Dec;
130(2):213-223.
PMID: 38042958
Background: The determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in colorectal cancer (CRC) are poorly understood. Here, we hypothesized that distinct immune and...
3.
Strating E, Verhagen M, Wensink E, Dunnebach E, Wijler L, Aranguren I, et al.
Front Immunol
. 2023 Jun;
14:1053920.
PMID: 37261365
Background: Poor prognosis in colon cancer is associated with a high content of cancer-associated fibroblasts (CAFs) and an immunosuppressive tumor microenvironment. The relationship between these two features is incompletely understood....
4.
Kucukkose E, Laoukili J, Gorelick A, Degner S, Lacle M, van den Bent L, et al.
Gastroenterology
. 2023 Mar;
165(2):429-444.e15.
PMID: 36906044
Background & Aims: Patients with colon cancer with liver metastases may be cured with surgery, but the presence of additional lung metastases often precludes curative treatment. Little is known about...
5.
Kucukkose E, Heesters B, Villaudy J, Verheem A, Cercel M, van Hal S, et al.
J Immunother Cancer
. 2022 Dec;
10(12).
PMID: 36543378
Background: The immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint blockade (ICB). However, resistance to ICB is commonly observed, and...
6.
Laoukili J, van Schelven S, Kucukkose E, Verheem A, Goey K, Koopman M, et al.
Cell Rep
. 2022 Nov;
41(9):111728.
PMID: 36450250
The presence of BRAF in colorectal cancer (CRC) is associated with a higher chance of distant metastasis. Oxidative stress in disseminated tumor cells limits metastatic capacity. To study the relationship...
7.
Kucukkose E, Peters N, Ubink I, van Keulen V, Daghighian R, Verheem A, et al.
Cell Death Dis
. 2022 Jul;
13(7):617.
PMID: 35842424
Expression profiling has identified four consensus molecular subtypes (CMS1-4) in colorectal cancer (CRC). The receptor tyrosine kinase KIT has been associated with the most aggressive subtype, CMS4. However, it is...
8.
Laoukili J, Constantinides A, Wassenaar E, Elias S, Raats D, van Schelven S, et al.
Br J Cancer
. 2022 Feb;
126(12):1824-1833.
PMID: 35194192
Background: Peritoneal metastases (PM) in colorectal cancer (CRC) are associated with therapy resistance and poor survival. Oxaliplatin monotherapy is widely applied in the intraperitoneal treatment of PM, but fails to...
9.
Poghosyan S, Frenkel N, Lentzas A, Laoukili J, Borel Rinkes I, Kranenburg O, et al.
Cancers (Basel)
. 2022 Feb;
14(3).
PMID: 35158941
Neuropilin-2 (Nrp2), an important regulator of lymphangiogenesis and lymphatic metastasis, has been associated with progression in colorectal cancer (CRC). However, the tumor cell-intrinsic role of Nrp2 in cancer progression is...
10.
Kucukkose E, Wensink G, Roelse C, van Schelven S, Raats D, Boj S, et al.
Cancers (Basel)
. 2021 Nov;
13(21).
PMID: 34771595
DNA mismatch repair deficiency (dMMR) in metastatic colorectal cancer (mCRC) is associated with poor survival and a poor response to systemic treatment. However, it is unclear whether dMMR results in...