James Wheless
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Explore the profile of James Wheless including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Lyons P, Wheless J, Verner R, Ferreira J, Liow K, Valeriano J, et al.
Epilepsia
. 2025 Feb;
PMID: 39921595
Objective: The drug-resistant epilepsy associated with Lennox-Gastaut syndrome (LGS) has a long-term effect on patients and is difficult to treat with conventional pharmacological and nonpharmacological therapies. Our objective is to...
2.
Motiwala M, Tambi S, Motiwala A, Dacus M, Troy C, Osorno-Cruz C, et al.
J Neurosurg Pediatr
. 2024 Dec;
35(3):276-283.
PMID: 39642376
Objective: Corpus callosotomy is an effective treatment for atonic seizures in patients with medically refractory epilepsy. A large modern series of corpus callosotomies performed via open craniotomy highlights the importance...
3.
Wheless J, Weatherspoon S
Pediatr Neurol
. 2024 Nov;
162:76-86.
PMID: 39571208
Dravet syndrome is a developmental and epileptic encephalopathy characterized by frequent, prolonged convulsive seizures and status epilepticus. Symptoms usually appear in the first year of life, and in addition to...
4.
Chourasia N, Vaidya R, Sengupta S, Mefford H, Wheless J
Pediatr Neurol
. 2024 Oct;
161:101-107.
PMID: 39357456
Background: The interpretation and communication of variant of uncertain significance (VUS) genetic results often present a challenge in clinical practice. VUSs can be reclassified over time into benign/likely benign (B/LB)...
5.
Shah S, Gonzalez Gutierrez E, Hopp J, Wheless J, Gil-Nagel A, Krauss G, et al.
Epilepsy Behav
. 2024 Jul;
158():109908.
PMID: 38964183
Objective: Evaluate the performance of a custom application developed for tonic-clonic seizure (TCS) monitoring on a consumer-wearable (Apple Watch) device. Methods: Participants with a history of convulsive epileptic seizures were...
6.
Chourasia N, Dohmeier J, Curry J, Parkhurst S, Mudigoudar B, Rivas-Coppola M, et al.
Pediatr Neurol
. 2024 Jun;
157:134-140.
PMID: 38917517
Background: Lacosamide (LCM) is a third-generation antiseizure medication (ASM) currently approved for the treatment of focal seizures in children aged greater than one month. There are limited data on its...
7.
Moretz K, Wheless J, Santos C, Segal E, Lancman M, Patten A, et al.
Eur J Paediatr Neurol
. 2024 Apr;
50:23-30.
PMID: 38569352
Introduction: The non-interventional Phase IV PROVE study (NCT03208660) assessed retention, efficacy, safety and tolerability, and perampanel dosing in patients with epilepsy during routine clinical care. This analysis evaluated final data...
8.
Wheless J, Gidal B, Gong L, Lyu S, Zheng X, Li R, et al.
Epilepsy Res
. 2024 Mar;
202:107350.
PMID: 38513537
Objectives: Assess the bioequivalence of lacosamide extended-release (XR) capsules and immediate-release (IR) tablets and answer real-world clinical questions regarding the use of lacosamide XR. Methods: An open-label, randomized, two-treatment, two-sequence,...
9.
Misra S, Sperling M, Rao V, Peters J, Penovich P, Wheless J, et al.
Epilepsy Behav Rep
. 2024 Jan;
25:100644.
PMID: 38274142
For acute treatment of seizure clusters in patients with epilepsy, intranasal administration of acute seizure therapies has been shown to provide accessibility and ease of use to care partners as...
10.
Noorizadeh N, Varner J, Birg L, Williard T, Rezaie R, Wheless J, et al.
Neuroimage Clin
. 2024 Jan;
41:103562.
PMID: 38215622
Non-invasive methods such as Transcranial Magnetic Stimulation (TMS) and magnetoencephalography (MEG) aid in the pre-surgical evaluation of patients with epilepsy or brain tumor to identify sensorimotor cortices. MEG requires sedation...