James W Jorgenson
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Explore the profile of James W Jorgenson including associated specialties, affiliations and a list of published articles.
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47
Citations
427
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Recent Articles
1.
Sorensen M, Miller K, Jorgenson J, Kennedy R
J Chromatogr A
. 2022 Dec;
1687:463707.
PMID: 36516490
Comprehensive characterization of the lipidome remains a challenge requiring development of new analytical approaches to expand lipid coverage in complex samples. In this work, offline two-dimensional liquid chromatography-mass spectrometry was...
2.
Miller K, Jorgenson J
J Sep Sci
. 2020 Sep;
43(22):4094-4102.
PMID: 32946185
Biological samples in lipidomic studies can consist of extremely complex mixtures due to the diverse range of species and isomerism. Herein, highly efficient, in-house packed microcapillary columns introduce the potential...
3.
Sorensen M, Miller K, Jorgenson J, Kennedy R
J Chromatogr A
. 2019 Oct;
1611:460575.
PMID: 31607445
Improvements in sample preparation, separation, and mass spectrometry continue to expand the coverage in LC-MS based lipidomics. While longer columns packed with smaller particles in theory give higher separation performance...
4.
Mozziconacci O, Stobaugh J, Bommana R, Woods J, Franklin E, Jorgenson J, et al.
Chromatographia
. 2019 Jan;
80(9):1299-1318.
PMID: 30686829
In recent years protein therapeutics have seen increasing use in the therapeutic arena. As with traditional small molecule drug substances, one is obligated to ensure purity and stability of the...
5.
Reising A, Godinho J, Bernzen J, Jorgenson J, Tallarek U
J Chromatogr A
. 2018 Jul;
1569:44-52.
PMID: 30001899
We study axial heterogeneities in capillary ultrahigh pressure liquid chromatography (UHPLC) columns through kinetic performance and bed morphological analysis. Two columns are used in this work, a 75 μm i.d. ...
6.
Lunn D, Yun Y, Jorgenson J
J Chromatogr A
. 2017 Nov;
1530:112-119.
PMID: 29157608
The study of metabolites in biological samples is of high interest for a wide range of biological and pharmaceutical applications. Reversed phase liquid chromatography is a common technique used for...
7.
Henley W, He Y, Mellors J, Batz N, Ramsey J, Jorgenson J
J Chromatogr A
. 2017 Aug;
1523:72-79.
PMID: 28811102
Ultra-high voltage capillary electrophoresis with high electric field strength has been applied to the separation of the charge variants, drug conjugates, and disulfide isomers of monoclonal antibodies. Samples composed of...
8.
Chun H, Dennis P, Ferguson Welch E, Alarie J, Jorgenson J, Ramsey J
J Chromatogr A
. 2017 Jul;
1523:140-147.
PMID: 28668370
The development and application of polyelectrolytic gel electrodes (PGEs) for a microfluidic photothermal absorbance detection system is described. The PGEs are used to measure changes in conductivity based on heat...
9.
Reising A, Godinho J, Jorgenson J, Tallarek U
J Chromatogr A
. 2017 May;
1504:71-82.
PMID: 28511930
Column wall effects and the formation of larger voids in the bed during column packing are factors limiting the achievement of highly efficient columns. Systematic variation of packing conditions, combined...
10.
Slechtova T, Gilar M, Kalikova K, Moore S, Jorgenson J, Tesarova E
J Chromatogr A
. 2017 Feb;
1490:126-132.
PMID: 28215403
Trypsin is the most widely used enzyme in proteomic research due to its high specificity. Although the in-solution digestion is predominantly used, it has several drawbacks, such as long digestion...