James S Trimmer
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Explore the profile of James S Trimmer including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
4835
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Recent Articles
1.
Ferns M, van der List D, Vierra N, Lacey T, Murray K, Kirmiz M, et al.
J Neurosci
. 2025 Feb;
PMID: 39933932
Voltage-gated K channels of the Kv2 family are highly expressed in brain and play dual roles in regulating neuronal excitability and in organizing endoplasmic reticulum - plasma membrane (ER-PM) junctions....
2.
Kahn R, Virk H, Laflamme C, Houston D, Polinski N, Meijers R, et al.
Elife
. 2024 Aug;
13.
PMID: 39140332
Antibodies are used in many areas of biomedical and clinical research, but many of these antibodies have not been adequately characterized, which casts doubt on the results reported in many...
3.
Han X, Lu X, Li P, Wang S, Schalek R, Meirovitch Y, et al.
Nat Commun
. 2024 Aug;
15(1):6648.
PMID: 39103318
Mapping neuronal networks is a central focus in neuroscience. While volume electron microscopy (vEM) can reveal the fine structure of neuronal networks (connectomics), it does not provide molecular information to...
4.
Ferns M, van der List D, Vierra N, Lacey T, Murray K, Kirmiz M, et al.
bioRxiv
. 2024 Feb;
PMID: 38328147
Voltage-gated K channels of the Kv2 family are highly expressed in brain and play dual roles in regulating neuronal excitability and in organizing endoplasmic reticulum - plasma membrane (ER-PM) junctions....
5.
Alexander S, Mathie A, Peters J, Veale E, Striessnig J, Kelly E, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S145-S222.
PMID: 38123150
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
6.
Matsumoto C, ODwyer S, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, et al.
Commun Biol
. 2023 Nov;
6(1):1165.
PMID: 37963972
In arterial myocytes, the canonical function of voltage-gated Ca1.2 and K2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively. Paradoxically, K2.1 also plays...
7.
Micheva K, Gong B, Collman F, Weinberg R, Smith S, Trimmer J, et al.
eNeuro
. 2023 Nov;
10(12).
PMID: 37945352
Antibody (Ab)-based imaging techniques rely on reagents whose performance may be application specific. Because commercial antibodies are validated for only a few purposes, users interested in other applications may have...
8.
Mitchell K, Gong B, Hunter S, Burkart-Waco D, Gavira-ONeill C, Templeton K, et al.
Sci Rep
. 2023 Sep;
13(1):16200.
PMID: 37758930
The Neuroscience Monoclonal Antibody Sequencing Initiative (NeuroMabSeq) is a concerted effort to determine and make publicly available hybridoma-derived sequences of monoclonal antibodies (mAbs) valuable to neuroscience research. Over 30 years...
9.
Vierra N, Ribeiro-Silva L, Kirmiz M, van der List D, Bhandari P, Mack O, et al.
Nat Commun
. 2023 Aug;
14(1):5231.
PMID: 37633939
Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular signaling machinery near ER-PM junctions allows these domains...
10.
Casas M, Murray K, Hino K, Vierra N, Simo S, Trimmer J, et al.
Nat Commun
. 2023 Jul;
14(1):4553.
PMID: 37507375
Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is...