James S Harvey
Overview
Explore the profile of James S Harvey including associated specialties, affiliations and a list of published articles.
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18
Citations
197
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Recent Articles
1.
Ponting D, Czich A, Felter S, Glowienke S, Harvey J, Nudelman R, et al.
Regul Toxicol Pharmacol
. 2024 Dec;
156:105762.
PMID: 39662665
The carcinogenic potency categorisation approach (CPCA) has recently been introduced by health authorities. In this model, structural features from recent literature, industry proposals, and analyses performed by health authorities, provide...
2.
Ko V, Ong K, Kwon D, Li X, Pietrasiewicz A, Harvey J, et al.
Acta Neuropathol Commun
. 2024 Dec;
12(1):187.
PMID: 39633494
Hyperphosphorylated TDP-43 aggregates in the cytoplasm of motor neurons is a neuropathological signature of amyotrophic lateral sclerosis (ALS). These aggregates have been proposed to possess a toxic disease driving role...
3.
Thomas D, Wills J, Burman M, Williams A, Harte D, Buckley R, et al.
Mutagenesis
. 2024 Nov;
PMID: 39485309
The in vitro Bacterial Reverse Mutation (Ames) Test is crucial for evaluating the mutagenicity of pharmaceutical impurities. For N-nitrosamines (NAs) historical data indicated that for certain members of this chemical...
4.
Lynch A, Howe J, Hildebrand D, Harvey J, Burman M, Harte D, et al.
Mutagenesis
. 2024 Jan;
39(2):96-118.
PMID: 38183622
The N-nitrosamine, N-nitrosodimethylamine (NDMA), is an environmental mutagen and rodent carcinogen. Small levels of NDMA have been identified as an impurity in some commonly used drugs, resulting in several product...
5.
Yang H, Obrezanova O, Pointon A, Stebbeds W, Francis J, Beattie K, et al.
Toxicol Appl Pharmacol
. 2022 Dec;
459:116342.
PMID: 36502871
Functional changes to cardiomyocytes are undesirable during drug discovery and identifying the inotropic effects of compounds is hence necessary to decrease the risk of cardiovascular adverse effects in the clinic....
6.
Yang H, Stebbeds W, Francis J, Pointon A, Obrezanova O, Beattie K, et al.
Stem Cell Reports
. 2022 Feb;
17(3):556-568.
PMID: 35148844
Human induced pluripotent stem cell-derived cardiomyocytes have been established to detect dynamic calcium transients by fast kinetic fluorescence assays that provide insights into specific aspects of clinical cardiac activity. However,...
7.
Shlevkov E, Murugan P, Montagna D, Stefan E, Hadzipasic A, Harvey J, et al.
iScience
. 2022 Jan;
25(1):103650.
PMID: 35024585
Pharmacological activation of the E3 ligase Parkin represents a rational therapeutic intervention for the treatment of Parkinson's disease. Here we identify several compounds that enhance the activity of wildtype Parkin...
8.
Hasselgren C, Ahlberg E, Akahori Y, Amberg A, Anger L, Atienzar F, et al.
Regul Toxicol Pharmacol
. 2019 Jun;
107:104403.
PMID: 31195068
In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for regulatory submissions, such as for assessing chemicals...
9.
Svensson F, Zoufir A, Mahmoud S, Afzal A, Smit I, Giblin K, et al.
Chem Res Toxicol
. 2018 Oct;
31(11):1119-1127.
PMID: 30350600
Adverse events resulting from drug therapy can be a cause of drug withdrawal, reduced and or restricted clinical use, as well as a major economic burden for society. To increase...
10.
Amberg A, Anger L, Bercu J, Bower D, Cross K, Custer L, et al.
Mutagenesis
. 2018 Sep;
34(1):67-82.
PMID: 30189015
(Quantitative) structure-activity relationship or (Q)SAR predictions of DNA-reactive mutagenicity are important to support both the design of new chemicals and the assessment of impurities, degradants, metabolites, extractables and leachables, as...