James R Dutton
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Explore the profile of James R Dutton including associated specialties, affiliations and a list of published articles.
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46
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1233
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Recent Articles
1.
Shang P, Ambrosino H, Hoang J, Geng Z, Zhu X, Shen S, et al.
Free Radic Biol Med
. 2024 Nov;
225():833-845.
PMID: 39491736
Age-related macular degeneration (AMD), the leading cause of central vision loss in the elderly, involves death of the retinal pigment epithelium (RPE) and light-sensing photoreceptors. This multifactorial disease includes contributions...
2.
Simon N, Kim Y, Gribnau J, Bautista D, Dutton J, Brem R
Heredity (Edinb)
. 2024 Oct;
133(5):370.
PMID: 39448876
No abstract available.
3.
Simon N, Kim Y, Gribnau J, Bautista D, Dutton J, Brem R
Heredity (Edinb)
. 2024 Aug;
133(5):308-316.
PMID: 39164520
A key goal of evolutionary genomics is to harness molecular data to draw inferences about selective forces that have acted on genomes. The field progresses in large part through the...
4.
Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, et al.
Nat Commun
. 2024 Jul;
15(1):6150.
PMID: 39034314
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and...
5.
Simon N, Kim Y, Bautista D, Dutton J, Brem R
bioRxiv
. 2023 Jul;
PMID: 37503246
A key goal of evolutionary genomics is to harness molecular data to draw inferences about selective forces that have acted on genomes. The field progresses in large part through the...
6.
Fisher C, Ebeling M, Geng Z, Kapphahn R, Roehrich H, Montezuma S, et al.
Antioxidants (Basel)
. 2022 Apr;
11(4).
PMID: 35453289
Primary cultures of retinal pigment epithelium (RPE) from human adult donors (haRPE) and induced pluripotent stem cell derived-RPE (iPSC-RPE) are valuable model systems for gaining mechanistic insight and for testing...
7.
Lavoie N, Truong V, Malone D, Pengo T, Patil N, Dutton J, et al.
J Cell Mol Med
. 2022 Mar;
26(7):1932-1942.
PMID: 35257489
Numerous interventions have been explored in animal models using cells differentiated from human induced pluripotent stem cells (iPSCs) in the context of neural injury with some success. Our work seeks...
8.
Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration
Ebeling M, Geng Z, Stahl M, Kapphahn R, Roehrich H, Montezuma S, et al.
Pharmaceuticals (Basel)
. 2022 Jan;
15(1).
PMID: 35056119
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. No universally effective treatments exist for atrophic or "dry" AMD, which results from loss of the retinal...
9.
Li R, Walsh P, Truong V, Petersen A, Dutton J, Hubel A
Front Cell Dev Biol
. 2021 Dec;
9:796960.
PMID: 34970550
Differentiation of human induced pluripotent stem cells (hiPSCs) generates cell phenotypes valuable for cell therapy and personalized medicine. Successful translation of these hiPSC-derived therapeutic products will rely upon effective cryopreservation...
10.
Ebeling M, Geng Z, Kapphahn R, Roehrich H, Montezuma S, Dutton J, et al.
Cells
. 2021 Apr;
10(4).
PMID: 33918210
Age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, is characterized by loss of the retinal pigment epithelium (RPE). While the disease mechanism remains unclear, prior...