James Peddy
Overview
Explore the profile of James Peddy including associated specialties, affiliations and a list of published articles.
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6
Citations
272
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Recent Articles
1.
Jiang Y, Sachdeva K, Goulbourne C, Berg M, Peddy J, Stavrides P, et al.
bioRxiv
. 2024 Sep;
PMID: 39345644
Significance Statement: Dysfunction in the endolysosomal system within neurons is a key feature of Alzheimer's disease (AD). Multiple AD risk factors lead to hyperactivity of the early-endosome GTPase rab5, disrupting...
2.
Stavrides P, Goulbourne C, Peddy J, Huo C, Rao M, Khetarpal V, et al.
bioRxiv
. 2024 Jun;
PMID: 38854023
Huntington's disease (HD) is caused by expansion of the polyglutamine stretch in huntingtin protein (HTT) resulting in hallmark aggresomes/inclusion bodies (IBs) composed of mutant huntingtin protein (mHTT) and its fragments....
3.
Rao M, Darji S, Stavrides P, Goulbourne C, Kumar A, Yang D, et al.
Autophagy
. 2022 Sep;
19(4):1277-1292.
PMID: 36131358
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives enabling formation of large...
4.
Jiang Y, Alam J, Gomperts S, Maruff P, Lemstra A, Germann U, et al.
Nat Commun
. 2022 Sep;
13(1):5308.
PMID: 36130946
The endosome-associated GTPase Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α is...
5.
Lee J, Yang D, Goulbourne C, Im E, Stavrides P, Pensalfini A, et al.
Nat Neurosci
. 2022 Jun;
25(6):688-701.
PMID: 35654956
Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific...
6.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne C, Stavrides P, et al.
Cell Rep
. 2020 Nov;
33(8):108420.
PMID: 33238112
Neuronal endosomal dysfunction, the earliest known pathobiology specific to Alzheimer's disease (AD), is mediated by the aberrant activation of Rab5 triggered by APP-β secretase cleaved C-terminal fragment (APP-βCTF). To distinguish...