James P Garcia
Overview
Explore the profile of James P Garcia including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
147
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Recent Articles
1.
Terasawa E, Garcia J
Curr Opin Endocr Metab Res
. 2020 Oct;
14:145-151.
PMID: 33043166
An increase in pulsatile release of gonadotropin releasing hormone (GnRH) initiates puberty in mammalian species. While mutations in and and their receptors, and , respectively, result in the absence or...
2.
Garcia J, Keen K, Seminara S, Terasawa E
Semin Reprod Med
. 2019 Dec;
37(2):47-55.
PMID: 31847024
To understand the roles of kisspeptin and neurokinin B (NKB) in puberty and sex differences in their involvement, we conducted a series of experiments measuring the release of gonadotropin-releasing hormone...
3.
Garcia J, Keen K, Kenealy B, Seminara S, Terasawa E
Endocrinology
. 2018 Jul;
159(8):3048-3060.
PMID: 29982393
Despite the well-established concept that an increase in pulsatile GnRH release triggers puberty, the precise signaling mechanism responsible for the pubertal increase in GnRH release remains unclear. A recent study...
4.
Terasawa E, Garcia J, Seminara S, Keen K
Front Endocrinol (Lausanne)
. 2018 Apr;
9:148.
PMID: 29681889
In human patients, loss-of-function mutations in the genes encoding kisspeptin () and neurokinin B ( and their receptors ( and , respectively) result in an abnormal timing of puberty or...
5.
Kenealy B, Keen K, Garcia J, Kohlenberg L, Terasawa E
Proc Natl Acad Sci U S A
. 2017 Dec;
114(52):13804-13809.
PMID: 29229849
Negative and positive feedback effects of ovarian 17β-estradiol (E) regulating release of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) are pivotal events in female reproductive function. While ovarian feedback...
6.
Garcia J, Guerriero K, Keen K, Kenealy B, Seminara S, Terasawa E
Endocrinology
. 2017 Oct;
158(10):3269-3280.
PMID: 28977601
Loss-of-function or inactivating mutations in the genes coding for kisspeptin and its receptor (KISS1R) or neurokinin B (NKB) and the NKB receptor (NK3R) in humans result in a delay in...
7.
Kurian J, Keen K, Kenealy B, Garcia J, Hedman C, Terasawa E
Endocrinology
. 2015 Apr;
156(7):2563-70.
PMID: 25853665
Bisphenol A (BPA) is an industrial compound with pervasive distribution in the environments of industrialized countries. The U.S. Centers for Disease Control recently found that greater than 90% of Americans...
8.
Kenealy B, Keen K, Garcia J, Richter D, Terasawa E
Endocrinology
. 2015 Mar;
156(5):1804-14.
PMID: 25734362
Our recent study indicates that a brief infusion (20 min) of estradiol (E2) benzoate (EB) into the stalk-median eminence (S-ME) stimulates GnRH release with a latency of approximately 10 minutes....
9.
Kenealy B, Kapoor A, Guerriero K, Keen K, Garcia J, Kurian J, et al.
J Neurosci
. 2013 Dec;
33(49):19051-9.
PMID: 24305803
Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and...