James P B Lloyd
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Explore the profile of James P B Lloyd including associated specialties, affiliations and a list of published articles.
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191
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Recent Articles
1.
Lloyd J, Khan A, Lister R
Plant J
. 2025 Mar;
121(5):e70090.
PMID: 40052500
Synthetic gene circuits offer powerful new approaches for engineering plant traits by enabling precise control over gene expression through programmable logical operations. Unlike simple 'always-on' transgenes, circuits can integrate multiple...
2.
Cahn J, Lloyd J, Karemaker I, Jansen P, Pflueger J, Duncan O, et al.
Genome Res
. 2024 Dec;
34(12):2229-2243.
PMID: 39632087
In plants, cytosine DNA methylation (mC) is largely associated with transcriptional repression of transposable elements, but it can also be found in the body of expressed genes, referred to as...
3.
Khan M, Herring G, Zhu J, Oliva M, Fourie E, Johnston B, et al.
Nat Biotechnol
. 2024 May;
PMID: 38769424
The construction of synthetic gene circuits in plants has been limited by a lack of orthogonal and modular parts. Here, we implement a CRISPR (clustered regularly interspaced short palindromic repeats)...
4.
Roychoudhry S, Sageman-Furnas K, Wolverton C, Grones P, Tan S, Molnar G, et al.
Nat Plants
. 2023 Sep;
9(9):1500-1513.
PMID: 37666965
Lateral roots are typically maintained at non-vertical angles with respect to gravity. These gravitropic setpoint angles are intriguing because their maintenance requires that roots are able to effect growth response...
5.
Lloyd J, Ly F, Gong P, Pflueger J, Swain T, Pflueger C, et al.
Nat Biotechnol
. 2022 Jul;
40(12):1862-1872.
PMID: 35788565
Plant biotechnology predominantly relies on a restricted set of genetic parts with limited capability to customize spatiotemporal and conditional expression patterns. Synthetic gene circuits have the potential to integrate multiple...
6.
Lloyd J, Lister R
Nat Rev Genet
. 2021 Sep;
23(1):55-68.
PMID: 34526697
Plant intra-individual and inter-individual variation can be determined by the epigenome, a set of covalent modifications of DNA and chromatin that can alter genome structure and activity without changes to...
7.
Harris K, Lloyd J, Domb K, Zilberman D, Zemach A
Epigenetics Chromatin
. 2019 Oct;
12(1):62.
PMID: 31601251
Background: DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation...
8.
Lloyd J
F1000Res
. 2018 Dec;
7:1299.
PMID: 30345031
Nonsense-mediated mRNA decay is a eukaryotic pathway that degrades transcripts with premature termination codons (PTCs). In most eukaryotes, thousands of transcripts are degraded by NMD, including many important regulators of...
9.
Lloyd J, Lang D, Zimmer A, Causier B, Reski R, Davies B
Nucleic Acids Res
. 2018 Mar;
46(11):5822-5836.
PMID: 29596649
Nonsense-mediated mRNA decay (NMD) is important for RNA quality control and gene regulation in eukaryotes. NMD targets aberrant transcripts for decay and also directly influences the abundance of non-aberrant transcripts....
10.
Causier B, Li Z, De Smet R, Lloyd J, Van de Peer Y, Davies B
Sci Rep
. 2017 Dec;
7(1):16692.
PMID: 29192227
Nonsense-mediated mRNA decay (NMD) is an essential eukaryotic process regulating transcript quality and abundance, and is involved in diverse processes including brain development and plant defenses. Although some of the...