James Mu
Overview
Explore the profile of James Mu including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
3301
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Recent Articles
1.
Al-Khalil K, Bell R, Towe S, Cohen J, Gadde S, Mu J, et al.
Drug Alcohol Depend
. 2024 Aug;
263:112416.
PMID: 39197360
Background: Cocaine use (CU) is prevalent in people with HIV (PWH). Both conditions are linked to changes in cognitive functioning and neural network topology. The current study utilizes graph theory...
2.
Wu M, Carballo-Jane E, Zhou H, Zafian P, Dai G, Liu M, et al.
Nat Commun
. 2024 Jan;
15(1):688.
PMID: 38263326
No abstract available.
3.
Pissarnitski D, Kekec A, Yan L, Zhu Y, Feng D, Huo P, et al.
J Med Chem
. 2022 Mar;
65(7):5593-5605.
PMID: 35298158
We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of insulin as an antidiabetic...
4.
Wu M, Carballo-Jane E, Zhou H, Zafian P, Dai G, Liu M, et al.
Nat Commun
. 2022 Feb;
13(1):942.
PMID: 35177603
Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g....
5.
Wendling O, Hentsch D, Jacobs H, Lemercier N, Taubert S, Pertuy F, et al.
Biomedicines
. 2021 Aug;
9(7).
PMID: 34356832
3D imaging in animal models, during development or in adults, facilitates the identification of structural morphological changes that cannot be achieved with traditional 2D histological staining. Through the reconstruction of...
6.
Dutta K, Das R, Ling J, Monibas R, Carballo-Jane E, Kekec A, et al.
ACS Omega
. 2020 Jul;
5(28):17531-17542.
PMID: 32715238
Due to their relatively large molecular sizes and delicate nature, biologic drugs such as peptides, proteins, and antibodies often require high and repeated dosing, which can cause undesired side effects...
7.
Wang Y, Zhou H, Palyha O, Mu J
JCI Insight
. 2019 Aug;
4(15).
PMID: 31391336
Type 2 diabetes mellitus (T2DM), also known as adult-onset diabetes, is characterized by ineffective insulin action due to insulin resistance in key metabolic tissues. Insulin receptor (IR) plays an important...
8.
Kaarsholm N, Lin S, Yan L, Kelly T, van Heek M, Mu J, et al.
Diabetes
. 2018 Mar;
67(5):1030.
PMID: 29487114
No abstract available.
9.
Yang R, Wu M, Lin S, Nargund R, Li X, Kelly T, et al.
JCI Insight
. 2018 Jan;
3(1).
PMID: 29321379
Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying insulin to render its glucose-responsive release from an injection depot (of an insulin...
10.
Kaarsholm N, Lin S, Yan L, Kelly T, van Heek M, Mu J, et al.
Diabetes
. 2017 Nov;
67(2):299-308.
PMID: 29097375
Insulin has a narrow therapeutic index, reflected in a small margin between a dose that achieves good glycemic control and one that causes hypoglycemia. Once injected, the clearance of exogenous...