James Melhorn
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Explore the profile of James Melhorn including associated specialties, affiliations and a list of published articles.
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13
Citations
289
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Recent Articles
1.
Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment
Lavoie G, Howell I, Melhorn J, Borg C, Bermejo-Sanchez L, Seymour J, et al.
Thorax
. 2024 Dec;
80(2):113-116.
PMID: 39694544
Macrolides reduce exacerbations when added to inhaled therapy in severe asthma. However, there is little published evidence for effectiveness in patients treated with biologics. We conducted a retrospective audit of...
2.
Ramakrishnan S, Russell R, Mahmood H, Krassowska K, Melhorn J, Mwasuku C, et al.
Lancet Respir Med
. 2024 Nov;
13(1):59-68.
PMID: 39615502
Background: Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are important events and are associated with critical illness. Eosinophilic inflammation is a treatable trait commonly found during acute exacerbations...
3.
Pelaia C, Melhorn J, Hinks T, Couillard S, Vatrella A, Pelaia G, et al.
Expert Rev Respir Med
. 2024 Jul;
18(7):485-498.
PMID: 38994712
Introduction: The hallmark of most patients with severe asthma is type 2 inflammation, driven by innate and adaptive immune responses leading to either allergic or non-allergic eosinophilic infiltration of airways....
4.
5.
Melhorn J, Thomas J, Pavord I
NEJM Evid
. 2024 Feb;
2(1):EVIDe2200299.
PMID: 38320096
Inducible laryngeal obstruction (ILO)/vocal cord dysfunction is frequently encountered in the specialist asthma clinic, where it is often misdiagnosed as asthma or is coexistent with asthma. It causes recurrent distressing...
6.
Howell I, Mahdi M, Bafadhel M, Hinks T, Ramakrishnan S, Melhorn J, et al.
JMIR Res Protoc
. 2023 Jun;
12:e46741.
PMID: 37351918
Background: Asthma attacks are a common and important problem. Someone experiences an asthma attack in the United Kingdom every 10 seconds. Asthma attacks cause coughing, wheezing, breathlessness, and chest tightness...
7.
Melhorn J, Alamoudi A, Mentzer A, Fraser E, Fries A, Cassar M, et al.
Front Med (Lausanne)
. 2023 Feb;
10:1056506.
PMID: 36844209
Background And Aim: In acute severe COVID-19, patients present with lung inflammation and vascular injury, accompanied by an exaggerated cytokine response. In this study, our aim was to describe the...
8.
Melhorn J, Howell I, Pavord I
Ann Allergy Asthma Immunol
. 2022 Feb;
128(4):390-397.
PMID: 35172180
Objective: To explore the evidence for adopting a "treatable traits" approach to asthma management. Data Sources: PubMed, Medline, and Google Scholar. Study Selections: The above-mentioned databases were searched for randomized,...
9.
Melhorn J, Achaiah A, Conway F, Thompson E, Skyllberg E, Durrant J, et al.
Eur Respir J
. 2022 Feb;
60(3.
PMID: 35144988
Background: There is an emerging understanding that coronavirus disease 2019 (COVID-19) is associated with increased incidence of pneumomediastinum (PTM). We aimed to determine its incidence among patients hospitalised with COVID-19...
10.
Couillard S, Laugerud A, Jabeen M, Ramakrishnan S, Melhorn J, Hinks T, et al.
Thorax
. 2021 Aug;
77(2):199-202.
PMID: 34362839
Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil...