James McCullagh
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Explore the profile of James McCullagh including associated specialties, affiliations and a list of published articles.
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37
Citations
1191
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Recent Articles
1.
Arman B, Clarke R, Bharucha T, Fernandez L, Walsby-Tickle J, Deats M, et al.
NPJ Vaccines
. 2025 Jan;
10(1):19.
PMID: 39885196
The rapid development and worldwide distribution of COVID-19 vaccines is a remarkable achievement of biomedical research and logistical implementation. However, these developments are associated with the risk of a surge...
2.
McCullagh J, Probert F
Curr Opin Chem Biol
. 2024 May;
80:102466.
PMID: 38772215
Following in the footsteps of genomics and proteomics, metabolomics has revolutionised the way we investigate and understand biological systems. Rapid development in the last 25 years has been driven largely...
3.
Bharucha T, Gangadharan B, Clarke R, Fernandez L, Arman B, Walsby-Tickle J, et al.
Vaccine
. 2024 Feb;
42(7):1506-1511.
PMID: 38355318
Substandard (including degraded) and falsified (SF) vaccines are a relatively neglected issue with serious global implications for public health. This has been highlighted during the rapid and widespread rollout of...
4.
Mosca S, Lin Q, Stokes R, Bharucha T, Gangadharan B, Clarke R, et al.
Vaccine
. 2023 Oct;
41(47):6960-6968.
PMID: 37865599
Preventing, detecting, and responding to substandard and falsified vaccines is of critical importance for ensuring the safety, efficacy, and public trust in vaccines. This is of heightened importance in context...
5.
Abdul Kadir A, Stubbs B, Chong C, Lee H, Cole M, Carr C, et al.
J Physiol
. 2023 Feb;
601(7):1207-1224.
PMID: 36799478
In heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d-β-hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish anaplerosis. We determined the effects of...
6.
Misheva M, Johnson J, McCullagh J
Metabolites
. 2022 Dec;
12(12).
PMID: 36557276
Oxygenated polyunsaturated fatty acids (oxylipins) are bioactive molecules established as important mediators during inflammation. Different classes of oxylipins have been found to have opposite effects, e.g., pro-inflammatory prostaglandins and anti-inflammatory...
7.
Haythorne E, Lloyd M, Walsby-Tickle J, Tarasov A, Sandbrink J, Portillo I, et al.
Nat Commun
. 2022 Nov;
13(1):6754.
PMID: 36376280
Chronic hyperglycaemia causes a dramatic decrease in mitochondrial metabolism and insulin content in pancreatic β-cells. This underlies the progressive decline in β-cell function in diabetes. However, the molecular mechanisms by...
8.
Green C, Marjot T, Walsby-Tickle J, Charlton C, Cornfield T, Westcott F, et al.
Eur J Endocrinol
. 2022 Jan;
186(3):367-377.
PMID: 35038311
Objective: Metformin is a first-line pharmacotherapy in the treatment of type 2 diabetes, a condition closely associated with non-alcoholic fatty liver disease (NAFLD). Although metformin promotes weight loss and improves...
9.
Bolton C, Smillie C, Pandey S, Elmentaite R, Wei G, Argmann C, et al.
Gastroenterology
. 2021 Nov;
162(3):859-876.
PMID: 34780721
Background & Aims: Monogenic forms of inflammatory bowel disease (IBD) illustrate the essential roles of individual genes in pathways and networks safeguarding immune tolerance and gut homeostasis. Methods: To build...
10.
Skaripa-Koukelli I, Hauton D, Walsby-Tickle J, Thomas E, Owen J, Lakshminarayanan A, et al.
Cancer Metab
. 2021 Oct;
9(1):37.
PMID: 34649623
Background: Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2) ...