James M Sonner
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Explore the profile of James M Sonner including associated specialties, affiliations and a list of published articles.
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63
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1226
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Recent Articles
1.
Sonner J, Cantor R
Annu Rev Biophys
. 2013 Mar;
42:143-67.
PMID: 23451895
Volatile anesthetics serve as useful probes of a conserved biological process that is essential to the proper functioning of the central nervous system. A kinetic and thermodynamic analysis of their...
2.
Hsu T, Leiske D, Rosenfeld L, Sonner J, Fuller G
Langmuir
. 2013 Jan;
29(6):1948-55.
PMID: 23339286
3-Hydroxybutyric acid (also referred to as β-hydroxybutyric acid or BHB), a small molecule metabolite whose concentration is elevated in type I diabetes and diabetic coma, was found to modulate the...
3.
Rau V, Oh I, Liao M, Bodarky C, Fanselow M, Homanics G, et al.
Anesth Analg
. 2011 Aug;
113(3):500-4.
PMID: 21813630
Background: β3 containing γ-aminobutyric acid type A receptors (GABA(A)-Rs) mediate behavioral end points of IV anesthetics such as immobility and hypnosis. A knockout mouse with targeted forebrain deletion of the...
4.
Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(29):12143-8.
PMID: 21730130
Pentameric ligand-gated ion channels (pLGICs), which mediate chemo-electric signal transduction in animals, have been recently found in bacteria. Despite clear sequence and 3D structure homology, the phylogenetic distance between prokaryotic...
5.
Nury H, Van Renterghem C, Weng Y, Tran A, Baaden M, Dufresne V, et al.
Nature
. 2011 Jan;
469(7330):428-31.
PMID: 21248852
General anaesthetics have enjoyed long and widespread use but their molecular mechanism of action remains poorly understood. There is good evidence that their principal targets are pentameric ligand-gated ion channels...
6.
Speca D, Chihara D, Ashique A, Bowers M, Pierce-Shimomura J, Lee J, et al.
PLoS Genet
. 2010 Aug;
6(8).
PMID: 20714347
The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe the positional cloning and characterization of a new mouse mutation isolated in...
7.
Weng Y, Yang L, Corringer P, Sonner J
Anesth Analg
. 2009 Nov;
110(1):59-63.
PMID: 19933531
A prokaryotic member of the gamma-aminobutyric acid type A receptor superfamily (GLIC) was recently cloned from the cyanobacterium Gloeobacter violaceus, its function characterized, and its 3-dimensional x-ray diffraction crystal structure...
8.
Rau V, Iyer S, Oh I, Chandra D, Harrison N, Eger 2nd E, et al.
Anesth Analg
. 2009 Nov;
109(6):1816-22.
PMID: 19923508
Background: General anesthesia produces multiple end points including immobility, hypnosis, sedation, and amnesia. Tonic inhibition via gamma-aminobutyric acid type A receptors (GABA(A)-Rs) may play a role in mediating behavioral end...
9.
Weng Y, Hsu T, Zhao J, Nishimura S, Fuller G, Sonner J
Anesth Analg
. 2009 Apr;
108(5):1538-45.
PMID: 19372333
Introduction: Elevated concentrations of isovaleric (IVA), methylmalonic (MMA), and propionic acid are associated with impaired consciousness in genetic diseases (organic acidemias). We conjectured that part of the central nervous system...
10.
Milutinovic P, Zhao J, Sonner J
Anesth Analg
. 2008 Dec;
108(1):176-80.
PMID: 19095846
Introduction: Tolerance is observed for a variety of central nervous system depressants including ethanol, which is an anesthetic, but has not been convincingly demonstrated for a potent halogenated volatile anesthetic....