James M Fulcher
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Explore the profile of James M Fulcher including associated specialties, affiliations and a list of published articles.
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21
Citations
247
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Recent Articles
1.
Zemaitis K, Fulcher J, Kumar R, Degnan D, Lewis L, Liao Y, et al.
Clin Proteomics
. 2025 Mar;
22(1):9.
PMID: 40045235
Background: The Human Proteome Project has credibly detected nearly 93% of the roughly 20,000 proteins which are predicted by the human genome. However, the proteome is enigmatic, where alterations in...
2.
Kwon Y, Fulcher J, Pasa-Tolic L, Qian W
Expert Rev Proteomics
. 2024 Dec;
:1-10.
PMID: 39710940
Introduction: Spatial biology is an emerging interdisciplinary field facilitating biological discoveries through the use of spatial omics technologies. Recent advancements in spatial transcriptomics, spatial genomics (e.g. genetic mutations and epigenetic...
3.
Fulcher J, Markillie L, Mitchell H, Williams S, Engbrecht K, Degnan D, et al.
Nat Commun
. 2024 Dec;
15(1):10614.
PMID: 39638780
Single-cell multiomics provides comprehensive insights into gene regulatory networks, cellular diversity, and temporal dynamics. Here, we introduce nanoSPLITS (nanodroplet SPlitting for Linked-multimodal Investigations of Trace Samples), an integrated platform that...
4.
Kumar R, Zemaitis K, Fulcher J, Pasa-Tolic L
Curr Opin Biotechnol
. 2024 Mar;
87:103096.
PMID: 38432187
Biological organisms are multifaceted, intricate systems where slight perturbations can result in extensive changes in gene expression, protein abundance and/or activity, and metabolic flux. These changes occur at different timescales,...
5.
Zemaitis K, Fulcher J, Kumar R, Degnan D, Lewis L, Liao Y, et al.
bioRxiv
. 2024 Feb;
PMID: 38405958
Background: The Human Proteome Project has credibly detected nearly 93% of the roughly 20,000 proteins which are predicted by the human genome. However, the proteome is enigmatic, where alterations in...
6.
Fulcher J, Swensen A, Chen Y, Verchere C, Petyuk V, Qian W
Endocrinology
. 2023 Nov;
164(12).
PMID: 37967211
Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide (proIAPP), has been reported as an important feature of prediabetes and diabetes. Proinsulin processing includes removal of several C-terminal...
7.
Degnan D, Zemaitis K, Lewis L, McCue L, Bramer L, Fulcher J, et al.
J Am Soc Mass Spectrom
. 2023 Jul;
34(9):2061-2064.
PMID: 37523489
Due to its speed, accuracy, and adaptability to various sample types, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a popular method to identify molecular isotope profiles from biological samples....
8.
Chen Y, Taylor A, Fulcher J, Swensen A, Dai X, Komba M, et al.
Diabetes
. 2023 Jun;
72(9):1277-1288.
PMID: 37364047
Article Highlights: Carboxypeptidase E (Cpe) is an enzyme that removes the carboxy-terminal arginine and lysine residues from peptide precursors. Mutations in CPE lead to obesity and type 2 diabetes in...
9.
de Araujo C, Denorme F, Stephens W, Li Q, Cody M, Crandell J, et al.
Front Immunol
. 2023 Apr;
14:1171222.
PMID: 37063850
[This corrects the article DOI: 10.3389/fimmu.2022.1046574.].
10.
de Araujo C, Denorme F, Stephens W, Li Q, Cody M, Crandell J, et al.
Front Immunol
. 2023 Feb;
13:1046574.
PMID: 36733389
Introduction: Neutrophil extracellular traps (NETs) clear pathogens but may contribute Q8 pathogenically to host inflammatory tissue damage during sepsis. Innovative therapeutic agents targeting NET formation and their potentially harmful collateral...