James L Shen
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Explore the profile of James L Shen including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
187
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Recent Articles
1.
Wang R, Fortier T, Chai F, Miao G, Shen J, Restrepo L, et al.
Cell
. 2023 Aug;
186(19):4172-4188.e18.
PMID: 37633267
Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria, by autophagy plays an important role in cell health. Here, we describe a developmentally programmed selective ER clearance by autophagy....
2.
Shen J, OConnor K, Moni J, Zweizig S, Fitzgerald T, Ko E
Adv Radiat Oncol
. 2023 Jan;
8(1):101003.
PMID: 36711065
Purpose: Upfront radiation therapy consisting of brachytherapy with or without external beam radiation therapy is considered standard of care for patients with endometrial carcinoma who are unable to undergo surgical...
3.
4.
Shen J, Doherty J, Allen E, Fortier T, Baehrecke E
Cell Death Differ
. 2022 May;
29(11):2275-2287.
PMID: 35523956
Autophagy targets cytoplasmic materials for degradation, and influences cell health. Alterations in Atg6/Beclin-1, a key regulator of autophagy, are associated with multiple diseases. While the role of Atg6 in autophagy...
5.
Wang R, Miao G, Shen J, Fortier T, Baehrecke E
Curr Biol
. 2022 Feb;
32(6):1262-1274.e4.
PMID: 35134326
Autophagy targets cytoplasmic materials for degradation and influences cell health. Organelle contact and trafficking systems provide membranes for autophagosome formation, but how different membrane systems are selected for use during...
6.
Shen J, Fortier T, Wang R, Baehrecke E
J Cell Biol
. 2021 Aug;
220(11).
PMID: 34459871
Defects in autophagy cause problems in metabolism, development, and disease. The autophagic clearance of mitochondria, mitophagy, is impaired by the loss of Vps13D. Here, we discover that Vps13D regulates mitophagy...
7.
Shen J, Fortier T, Zhao Y, Wang R, Burmeister M, Baehrecke E
Curr Biol
. 2021 May;
31(14):3028-3039.e7.
PMID: 34019822
Mutations in Vps13D cause defects in autophagy, clearance of mitochondria, and human movement disorders. Here, we discover that Vps13D functions in a pathway downstream of Vmp1 and upstream of Marf/Mfn2....
8.
McMahon A, Rahman R, Jin H, Shen J, Fieldsend A, Luo W, et al.
Cell
. 2016 Apr;
165(3):742-53.
PMID: 27040499
RNA transcripts are bound and regulated by RNA-binding proteins (RBPs). Current methods for identifying in vivo targets of an RBP are imperfect and not amenable to examining small numbers of...