James Kramer
Overview
Explore the profile of James Kramer including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
401
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0
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Recent Articles
11.
Fermini B, Hancox J, Abi-Gerges N, Bridgland-Taylor M, Chaudhary K, Colatsky T, et al.
J Biomol Screen
. 2015 Jul;
21(1):1-11.
PMID: 26170255
For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce QT interval prolongation and Torsades de Pointes (TdP) arrhythmia has been conducted according to ICH...
12.
Kramer J, Obejero-Paz C, Myatt G, Kuryshev Y, Bruening-Wright A, Verducci J, et al.
Sci Rep
. 2013 Jul;
3:2100.
PMID: 23812503
Drug-induced block of the cardiac hERG (human Ether-à-go-go-Related Gene) potassium channel delays cardiac repolarization and increases the risk of Torsade de Pointes (TdP), a potentially lethal arrhythmia. A positive hERG...
13.
Israelowitz M, Rizvi S, Kramer J, von Schroeder H
Protein Eng Des Sel
. 2005 Jun;
18(7):329-35.
PMID: 15980018
A method is presented for generating computer models of biological tissues. The method uses properties of extracellular matrix proteins to predict the structure and physical chemistry of the elements that...