James H Segars
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Explore the profile of James H Segars including associated specialties, affiliations and a list of published articles.
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141
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2642
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Recent Articles
11.
Cayton Vaught K, Hazimeh D, Carter A, Devine K, Maher J, Maguire M, et al.
Reprod Sci
. 2022 Nov;
30(5):1528-1539.
PMID: 36401072
Granulosa cells (GCs) must respond appropriately to follicle-stimulating hormone (FSH) for proper follicle maturation. FSH activates protein kinase A (PKA) leading to phosphorylation of the cyclic AMP response element binding...
12.
ONeill K, Maher J, Laronda M, Duncan F, LeDuc R, Lujan M, et al.
Am J Obstet Gynecol
. 2022 Oct;
228(3):270-275.e4.
PMID: 36191605
The ovaries are the female gonads that are crucial for reproduction, steroid production, and overall health. Historically, the ovary was broadly divided into regions defined as the cortex, medulla, and...
13.
Taylor H, Li H, Carson S, Flores V, Pal L, Robbins J, et al.
BMJ Open
. 2022 Jun;
12(6):e052043.
PMID: 35715184
Introduction: Infertility is a common complication of endometriosis. While in vitro fertilisation-embryo transfer (IVF) successfully treats endometriosis-associated infertility, there is some evidence that pregnancy rates may be diminished in women...
14.
Cross C, Driggers P, McCarthy B, Diab M, Brennan J, Segars J
F S Sci
. 2022 May;
2(3):303-314.
PMID: 35560280
Objective: To determine if A-kinase anchoring protein 13 (AKAP13) interacts with the vitamin D receptor (VDR) to alter vitamin D-dependent signaling in fibroid cells. Uterine leiomyomas (fibroids) are characterized by...
15.
Islam M, Chen L, Segars J
Clin Obstet Gynecol
. 2021 Sep;
64(4):813-836.
PMID: 34524172
Common benign gynecologic conditions such as uterine fibroids and endometriosis are linked to chronic pelvic pain, abnormal and heavy uterine bleeding, and infertility. Effective medical management of these diseases is...
16.
Afrin S, El Sabeh M, Islam M, Miyashita-Ishiwata M, Malik M, Catherino W, et al.
Pharmacol Res
. 2021 Aug;
172:105856.
PMID: 34461224
Uterine leiomyomas or fibroids are the most common tumors of the female reproductive tract. Estrogen (E), a steroid-derived hormone, and its receptors (ERs), particularly ER-α, are important drivers for the...
17.
Islam M, Afrin S, Singh B, Jayes F, Brennan J, Borahay M, et al.
Clin Transl Med
. 2021 Jul;
11(7):e475.
PMID: 34323413
Background: Uterine fibroids are highly prevalent, collagen-rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid...
18.
Kino T, Burd I, Segars J
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34201797
The coronavirus disease 2019 (COVID-19) caused by infection of the severe respiratory syndrome coronavirus-2 (SARS-CoV-2) significantly impacted human society. Recently, the synthetic pure glucocorticoid dexamethasone was identified as an effective...
19.
Singh B, Sims H, Trueheart I, Simpson K, Wang K, Patzkowsky K, et al.
Reprod Sci
. 2021 Apr;
28(9):2699-2709.
PMID: 33914296
Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however,...
20.
Islam M, Akhtar M, Segars J
Fertil Steril
. 2021 Apr;
115(6):1451-1452.
PMID: 33863554
No abstract available.