James H Marden
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Explore the profile of James H Marden including associated specialties, affiliations and a list of published articles.
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46
Citations
1111
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Recent Articles
1.
Treidel L, Deem K, Salcedo M, Dickinson M, Bruce H, Darveau C, et al.
Integr Comp Biol
. 2024 Jul;
PMID: 38982327
The evolution of flight in an early winged insect ancestral lineage is recognized as a key adaptation explaining the unparalleled success and diversification of insects. Subsequent transitions and modifications to...
2.
Ajenu E, Seideneck A, Pandellapalli E, Shinsky E, Humphries C, Aparicio N, et al.
PLoS One
. 2024 Mar;
19(3):e0297661.
PMID: 38442133
Cigarette smoke-induced protein aggregation damages the lung cells in emphysema and COPD; however, lung cancer cells continue to thrive, evolving to persist in the toxic environment. Here, we showed that...
3.
Winters N, Wafula E, Knollenberg B, Hamala T, Timilsena P, Perryman M, et al.
BMC Biol
. 2024 Feb;
22(1):38.
PMID: 38360697
Background: Plants have complex and dynamic immune systems that have evolved to resist pathogens. Humans have worked to enhance these defenses in crops through breeding. However, many crops harbor only...
4.
Stump S, Marden J, Beckman N, Mangan S, Comita L
Am Nat
. 2020 Sep;
196(4):472-486.
PMID: 32970465
AbstractSpecialized pathogens are thought to maintain plant community diversity; however, most ecological studies treat pathogens as a black box. Here we develop a theoretical model to test how the impact...
5.
Marden J, Langford E, Robertson M, Fescemyer H
Evolution
. 2020 Sep;
75(1):116-129.
PMID: 32895932
Genes with opposing effects on fitness at different life stages are the mechanistic basis for evolutionary theories of aging and life history. Examples come from studies of mutations in model...
6.
Portman S, Felton G, Kariyat R, Marden J
J Exp Biol
. 2020 Jul;
223(Pt 16).
PMID: 32647018
Insects manifest phenotypic plasticity in their development and behavior in response to plant defenses, via molecular mechanisms that produce tissue-specific changes. Phenotypic changes might vary between species that differ in...
7.
Porras M, Navas C, Marden J, Mescher M, De Moraes C, Pincebourde S, et al.
Nat Commun
. 2020 Mar;
11(1):1184.
PMID: 32132537
Vector-borne pathogens are known to alter the phenotypes of their primary hosts and vectors, with implications for disease transmission as well as ecology. Here we show that a plant virus,...
8.
Lawanprasert A, Guinan C, Langford E, Hawkins C, Sloand J, Fescemyer H, et al.
PLoS One
. 2020 Feb;
15(2):e0229467.
PMID: 32097449
Glycans are multi-branched sugars that are displayed from lipids and proteins. Through their diverse polysaccharide structures they can potentiate a myriad of cellular signaling pathways involved in development, growth, immuno-communication...
9.
Subramanian S, Maurer A, Bator C, Makhov A, Conway J, Turner K, et al.
Hum Gene Ther
. 2019 Sep;
30(12):1449-1460.
PMID: 31530236
Adeno-associated viruses (AAVs) have been employed successfully as gene therapy vectors in treating various genetic diseases for almost two decades. However, transgene packaging is usually imperfect, and developing a rapid...
10.
Hamala T, Guiltinan M, Marden J, Maximova S, dePamphilis C, Tiffin P
Mol Biol Evol
. 2019 Sep;
37(1):110-123.
PMID: 31501906
Separating footprints of adaptation from demography is challenging. When selection has acted on a single locus with major effect, this issue can be alleviated through signatures left by selective sweeps....