James H Girsch
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Explore the profile of James H Girsch including associated specialties, affiliations and a list of published articles.
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8
Citations
37
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Recent Articles
1.
Stewart C, Siegler E, Sakemura R, Cox M, Huynh T, Kimball B, et al.
Nat Commun
. 2024 Sep;
15(1):7921.
PMID: 39266501
Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three...
2.
Sirpilla O, Sakemura R, Hefazi M, Huynh T, Can I, Girsch J, et al.
Nat Biomed Eng
. 2024 Apr;
8(4):443-460.
PMID: 38561490
Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many disorders of the immune system. However, clinical trials using MSCs have shown inconsistent therapeutic efficacy, mostly owing to...
3.
Negishi S, Girsch J, Siegler E, Bezerra E, Miyao K, Sakemura R
Front Pediatr
. 2024 Jan;
11:1305657.
PMID: 38283399
Clinical trials of anti-CD19 chimeric antigen receptor T (CART19) cell therapy have shown high overall response rates in patients with relapsed/refractory B-cell malignancies. CART19 cell therapy has been approved by...
4.
Sakemura R, Manriquez Roman C, Horvei P, Siegler E, Girsch J, Sirpilla O, et al.
Blood
. 2023 Oct;
143(3):258-271.
PMID: 37879074
In the development of various strategies of anti-CD19 immunotherapy for the treatment of B-cell malignancies, it remains unclear whether CD19 monoclonal antibody therapy impairs subsequent CD19-targeted chimeric antigen receptor T-cell...
5.
Monroe J, Quach H, Punia S, Enninga E, Fedyshyn Y, Girsch J, et al.
J Infect Dis
. 2023 Oct;
229(2):473-484.
PMID: 37786979
Despite intensive characterization of immune responses after COVID-19 infection and vaccination, research examining protective correlates of vertical transmission in pregnancy are limited. Herein, we profiled humoral and cellular characteristics in...
6.
Girsch J, Mejia Plazas M, Olivier A, Farah M, Littlefield D, Behl S, et al.
Frontiers (Boulder)
. 2023 Feb;
2.
PMID: 36742289
In humans, the hemochorial placenta is a unique temporary organ that forms during pregnancy to support fetal development, gaseous exchange, delivery of nutrition, removal of waste products, and provides immune...
7.
Girsch J, Jackson W, Carpenter J, Moninger T, Jarosinski K, Grose C
J Virol
. 2020 Jun;
94(16).
PMID: 32493818
The literature on the egress of different herpesviruses after secondary envelopment is contradictory. In this report, we investigated varicella-zoster virus (VZV) egress in a cell line from a child with...
8.
Girsch J, Walters K, Jackson W, Grose C
J Virol
. 2019 Jun;
93(17).
PMID: 31217243
Varicella-zoster virus (VZV) is an alphaherpesvirus that lacks the herpesviral neurovirulence protein ICP34.5. The underlying hypothesis of this project was that inhibitors of autophagy reduce VZV infectivity. We selected the...