James Duffin
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Explore the profile of James Duffin including associated specialties, affiliations and a list of published articles.
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140
Citations
1800
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Recent Articles
1.
Eser P, Kaesermann D, Calamai P, Kalberer A, Stutz L, Huber S, et al.
Front Physiol
. 2025 Feb;
15:1509421.
PMID: 39911179
Background: In patients with chronic coronary syndromes (CCS), increased ventilation/carbon dioxide production ( / CO) slope has been found to predict disease progression and mortality, similarly to patients with heart...
2.
Cerebral perfusion metrics calculated directly from a hypoxia-induced step change in deoxyhemoglobin
Duffin J, Sayin E, Sobczyk O, Poublanc J, Mikulis D, Fisher J
Sci Rep
. 2024 Jul;
14(1):17121.
PMID: 39054379
Resting cerebral perfusion metrics can be calculated from the MRI ΔR* signal during the first passage of an intravascular bolus of a Gadolinium-based contrast agent (GBCA), or more recently, a...
3.
4.
Plitman E, Venkatraghavan L, Agrawal S, Raghavan V, Chowdhury T, Sobczyk O, et al.
Asian J Neurosurg
. 2024 Jul;
19(2):235-241.
PMID: 38974441
Controlling the partial pressure of carbon dioxide (PaCO ) is an important consideration in patients with intracranial steno-occlusive disease to avoid reductions in critical perfusion from vasoconstriction due to hypocapnia,...
5.
Stumpo V, Sayin E, Bellomo J, Sobczyk O, van Niftrik C, Sebok M, et al.
Front Physiol
. 2024 May;
15:1238533.
PMID: 38725571
Transient hypoxia-induced deoxyhemoglobin (dOHb) has recently been shown to represent a comparable contrast to gadolinium-based contrast agents for generating resting perfusion measures in healthy subjects. Here, we investigate the feasibility...
6.
Sayin E, Duffin J, Stumpo V, Bellomo J, Piccirelli M, Poublanc J, et al.
AJNR Am J Neuroradiol
. 2024 Jan;
45(1):37-43.
PMID: 38164571
Background And Purpose: Resting brain tissue perfusion in cerebral steno-occlusive vascular disease can be assessed by MR imaging using gadolinium-based susceptibility contrast agents. Recently, transient hypoxia-induced deoxyhemoglobin has been investigated...
7.
Sobczyk O, Sayin E, Poublanc J, Duffin J, Para A, Fisher J, et al.
AJNR Am J Neuroradiol
. 2024 Jan;
45(1):44-50.
PMID: 38164530
Background And Purpose: MR imaging-based cerebral perfusion metrics can be obtained by tracing the passage of a bolus of contrast through the microvasculature of the brain parenchyma. Thus, the temporal...
8.
Raghavan V, Sobczyk O, Sayin E, Poublanc J, Skanda A, Duffin J, et al.
J Magn Reson Imaging
. 2023 Dec;
60(3):954-961.
PMID: 38135486
Background: Cerebrovascular reactivity (CVR) is a measure of the change in cerebral blood flow (CBF) in response to a vasoactive challenge. It is a useful indicator of the brain's vascular...
9.
Huggard J, Guluzade N, Duffin J, Keir D
J Appl Physiol (1985)
. 2023 Nov;
135(6):1446-1456.
PMID: 37942527
Normobaric hyperoxia stimulates ventilation (V̇e) in a time- and dose-dependent manner. Whether this occurs via an oxygen (O)-specific mechanism or secondary to carbon dioxide (CO) retention at the central chemoreceptors...
10.
Sayin E, Duffin J, Poublanc J, Venkatraghavan L, Mikulis D, Fisher J, et al.
J Cereb Blood Flow Metab
. 2023 Aug;
43(12):2085-2095.
PMID: 37632334
Evaluation of cerebrovascular reactivity (CVR) to hypo- and hypercapnia is a valuable test for the assessment of vasodilatory reserve. While hypercapnia-induced CVR testing is usually performed at normoxia, mild hyperoxia...